Other NH Lymphoma

Question 1

What genetic translocation is associated with Follicular Lymphoma?

Answer 1

t(14;18) translocation of Bcl-2 gene

Question 2

What does the Bcl-2 gene code for?

Answer 2

An anti-apoptotic molecule

Question 3

What type of lymphoma is Follicular Lymphoma classified as?

Answer 3

Indolent NHL

Question 4

What is a common presentation of Follicular Lymphoma?

Answer 4

Waxing/waning painless neck mass over 1-2 years

Question 5

Mantel cell lymphoma translocation and significance

Answer 5

• t(11;14) translocation involving over-expression of cyclin D so can’t halt cell cycle.

Question 6

Mantle cell lymphoma mnemonic

Answer 6

For Mantle, I think of ages 11-14 being when most boys go through puberty (become a MANtle). A lot of boys this age are really into cyclin too.

Question 7

Mycosis fungoides description

Answer 7

• Cutaneous T-cell lymphoma characterized by cerebriform-shaped cells.

Question 8

Mycosis fungoides histo

Answer 8

• Cutaneous T-cell lymphoma characterized by cerebriform-shaped cells.

Question 9

Mycosis fungoides vs sezary syndrome

Answer 9

Less aggressive than the T-cell lymphoma of Sezary syndrome and does not extend to the
blood as a T-cell leukemia.

Question 10

Answer 10

Mycosis fungoides: An important differential for “skin rash.”