Ewing Sarcoma

Question 1

What are common symptoms of Ewing sarcoma?

Answer 1

bone tumor in a child that presents similarly to
osteomyelitis (i.e., fever and bone pain in a kid).

Question 2

In a bone scan, where does Ewing sarcoma typically show uptake?

Answer 2

Diaphysis

Question 3

In contrast to Ewing sarcoma, where does osteomyelitis typically show uptake in a bone scan?

Answer 3

Metaphysis

If bone scan is performed in Ewing sarcoma, it is most likely to show uptake in the diaphysis; in contrast, osteomyelitis will show uptake in the metaphysis

Question 4

What histological and imaging features are associated with Ewing sarcoma?

Answer 4

Small blue cells of neuroendocrine origin and/or onion-skinning

Question 5

What is a common description of Ewing sarcoma cells (histo) seen in answers?

Answer 5

Closely packed, small, round, uniform neoplastic cells

Question 6

What genetic translocation is associated with Ewing sarcoma?

Answer 6

t(11;22)

Question 7

What syndrome should not be confused with the t(11;22) translocation of Ewing sarcoma?

Answer 7

don’t confuse this with the 22q11 deletion in DiGeorge syndrome

Question 8

Answer 8

Ewing sarcoma: “small blue cells of neuroendocrine origin” and/or “closely packed, small, round, uniform neoplastic cells.”