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Flashcards in Immunology Deck (26):
0

Exaggerated response by immune system to foreign substance

Allergic Reaction

1

The two most common causes of fatal anaphylaxis?

Injected penicillin
Bee and wasps stings

400-800 deaths annually in US attributed to anaphylaxis

2

Principal body system involved in allergic reactions
Responsible for combating infection
Components found in blood, bone marrow, lymphatic system.

Immune system

3

Destruction or inactivation of pathogens, abnormal cells, foreign molecules such as toxins

Goals of immune response

4

Direct attack of foreign substance by specialized of immune system.

Cellular immunity

5

Chemical attack of invading substance

Humoral immunity

6

Principal chemical agents of this attack are?

Antibodies

7

Antibodies are manufactured by specialized cells of immune system called

B cells

8

Humoral immune response begins with exposure of body

Antigen

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Any substance capable of inducing a immune response

Antigen

10

Inital response to antigen

Several days are required before both cellular and humoral components of immune system respond

Primary response

11

Antibodies specific for offending antigen.

Antigen specific antibodies more effective

Secondary exposure

12

Inital exposure of individual to antigen ; results in immune response

Allergies

13

Most common cause of fatal anaphylaxis

Parentereal penicillin

14

Second most frequent cause of fatal anaphylaxis

Insect stings

15

IgE release histamine, heparin and other substances

De granulation

16

Principal chemical mediator of allergic reaction is

Histamine (

17

Potent substance which causes bronchoconstriction , increased intestinal motility, vasodilation, increased vascular permeability

Histamine

18

Cardiovascular
Respiratory
GI
And the skin
Are?

Principal body systems affected by anaphylaxis

19

End tidal CO2 level may climb due to development of both ?

Respiratory and metabolic acidosis

20

Cellular immunity

Involves direct attack of the foreign substance by specialized cells of the immune system.
*these cells physically engulf and deactivate or destroy offending agent*

21

Humoral immunity

Chemical attack of the invading substance
*The principal chemical agents of this attack are antibodies, also called immunoglobulin

22

Sensitization

The initial exposure of an individual to an antigen

23

Drugs
Food and food additives
Animals
Insects (Hymenoptera stings) and insect parts
Fungi and molds
Radiology contrast materials

Common allergies

24

H1 receptor

Smooth muscle, endothelial cells
-Acute allergic reactions

25

H2 receptor

Gastric parietal cells
-secretion of gastric acid