1.6.2013(vasculitis) 24 Flashcards
(144 cards)
0
Q
Granulomatous vasculitis
A
GCA
Takayasu
Wegener
Churg Strauss
1
Q
Cogan syndrome
A
Large vessel vasculitis
Interstitial keratitis
Vestibulitis
2
Q
P-ANCA
Antigen in MPO
A
Idiopathic crescentric glomerulonephritis
Good pasture
Churgstrauss
Microscopic polyangitis
3
Q
P ANCA
Not MPO
A
Rheumatoid vasculitis
Infective endocarditis
IBD
4
Q
Giant cell arteritis
Synonyms
A
Cranial arteries
Granulomatous arteritis
Temporal arteritis
5
Q
GCT artery spares
A
Intracranial vessels
No internal elastic lamina
6
Q
Most commonly involved artery in GCA
A
Superficial temporal artery
Other arteries:
Vertebral artery
Posterior ciliary branch of ophthalmic artery
7
Q
Polymyalgia rheumatica
A
Pain in neck,shoulder,pelvic girdle
Early morning joint stiffness
With high ESR
Excellent response to steroids
8
Q
Characteristic field defect in GCA
A
Altitudinal hemianopia
Due to anterior ischemic optic neuropathy
9
Q
GCA is unlikely in age less than
A
50yrs
10
Q
ESR 120-130
A
Milliary TB
Multiple myeloma
GCA
11
Q
Skip lesions
A
Crohn
GCA(temporal artery biopsy may be normal)
12
Q
Takayasu arteritis
Synonyms
A
Occlusive thromboaortapathy
Non specific aortoarteritis
Aortic arch syndrome
13
Q
Takayasu arteritis seen always in
A
Females
15-25yrs
14
Q
Commonest symptom in takayasu arteritis
A
Upper limb claudication
15
Q
Most common sign in takayasu arteritis
A
Subclavian and aortic bruit
16
Q
Hypertension in takayasu arteritis
A
Renovascular stenosis
17
Q
Most common presentation in B/L renal artery stenosis
A
Flash pulmonary Edema
18
Q
Diff btw GCA and takayasu arteritis
A
Takayasu involves renal artery
19
Q
Cerebral Edema,altered consciousness following accelerated hypertension
A
Posterior reversible encephalopathy syndrome(PRES)
20
Q
Aortic regurgitation in young girl
A
Takayasu arteritis causing aortic root dilatation
21
Q
Most common artery to be occluded in takayasu
A
Subclavian artery followed by aorta
22
Q
Giant cell arteritis in common in(gender)
A
Female 2:1
23
Q
Pulmonary artery involvement is seen in which large vessel arteritis
A
Takayasu
24
Wegener disease
Necrotising vasculitis with granuloma formation in URI,LRI,kidney
25
Diff btw generalised and limited wegener
Kidney not involved in limited
26
Most common URI manifestation of wegener
Serous otitis media
27
Midline T cell granuloma
Stewart's granuloma
28
Presentation of wegener
Serous otitis media
Recurrent sinusitis(staph aureus)
Midline nasal Deformity
Sub glottic stenosis
29
X ray findings of wegener
Nodules which can cavitate
| Diffuse b/l infiltrates
30
Glomerulonephritis urine routine
RBC casts
Dysmorphic RBC
Acanthocytes
Nephritic protenuria
31
Hematuria in a pt treated for wegener
| No casts
Cyclophosphamide
| Urinary bladder cancer
32
Poor prognostic sign in wegener
Ocular manifestation
33
Non renal complications of wegener
Ocular
| Peripheral neuropathy
34
IF in wegener
Pauci immune glomerulonephritis
35
Relapse in wegener is diagnosed by
C-ANCA
36
Necrotising vasculitis without granuloma
Microscopic polyangitis
37
100% association with microscopic polyangitis
Renal
38
Diffuse alveolar hemorrhage is seen in which small vessel vasculitis
Microscopic polyangitis
39
Skin manifestations are more common in which small vessel vasculitis
Microscopic polyangitis
Purpura
Urticaria
Vesiculobullous lesions
40
Diff btw PAN and microscopic PAN
Microscopic PAN
Lung involvement
Glomeruli involved
No hypertension
41
Peripheral neuropathy is common in which small vessel vasculitis
Wegener
| Churgstrauss
42
Churgstrauss
Necrotising vasculitis
Tissue eosinophilia
Extra vascular granuloma
43
Phases of churgstrauss
Allergic phase
| Vasculitic phase
44
Characteristic infiltrates in churgstrauss
Migratory infiltrates
45
Manifestation of churgstrauss
Asthma
Vasculitis
Peripheral neuropathy
46
Neuropathy in churgstrauss
Symmetric peripheral poly neuropathy
47
Most common cause of death in churgstrauss
Cardiac involvement
48
Progressive glomerulonephritis is uncommon in
Churgstrauss
49
Most commonly associated with neuropathy among small vessel vasculitis
Churgstrauss
CNS involvement can also be seen
50
PAN is common in(Gender )
Males
51
Hypertension with Hypokalemic periodic paralysis
Conn syndrome
52
Liddle syndrome is also known as
Pseudohyperaldosteronism
53
Liddle syndrome seen in
Teenage adult males(X linked)
54
Neuropathy associated with PAN
Mononeuritis multiplex
55
Hypertension with digital gangrene
PAN
56
Screening test to be done in PAN
HbSAg
57
Abdominal pain in PAN
Mesenteric vasculitis
58
Testicular pain is seen in which vasculitis
PAN
59
Urine routine in PAN
Normal
60
Classical pathological feature of PAN
Microaneurysms
61
Nerve biopsy preferred in PAN
Sural nerve
62
Most common small vessel vasculitis in children
HSP
63
Most common small vessel vasculitis in children <5yrs
Kawasaki
64
Kawasaki disease
Mucocutaneous lymphnode syndrome
65
Lymphnode involvement in Kawasaki
Non suppurative
| U/l lymphadenopathy
66
Commonest cardiac complication of Kawasaki
Myocarditis
67
Cardiac complications in Kawasaki
Myocarditis
Pericarditis
Coronary artery aneurysm(most dreaded complication)
68
Evidences for myocarditis in kawasaki
Low voltage QRS
Unexplained tachycardia
Refractory hypotension
69
Rx for acute phase of Kawasaki
Aspirin
| IVIG
70
Percent of Kawasaki pt with coronary artery involvement
25%
71
Kawasaki pt with coronary artery involvement
Aspirin
| Dipyridamole
72
CBC abnormality in Kawasaki
Thrombocytosis
73
Autosomal dominant CMT
Type 1 and 2
74
AR CMT
CMT 4
75
X linked dominant CMT
CMTX
76
Demyelinating CMT
CMT1
CMT2 Axonal neuropathy
77
Onion bulb is seen in
CMT1
78
Early onset and small muscle wasting in CMT
CMT1
79
AntiPo antibodies
CIDP
80
Anti GT1A1
Oculo pharyngeal cervicobrachial neuropathy
81
Antibodies in AMAN
GD1A
82
Commonest vasculitis in children
Henoch shonlein Purpura
83
HSP
Non thrombocytopenic palpable Purpura
84
Infections producing palpable Purpura
Gonococci
Meningiococci
RMSF
Ecthyma gangrenosum
85
Arthritis in HSP
Large joint
Migratory
Non deforming
86
Type of glomerulonephritis in HSP
Type 2
| Immune complex mediated RPGN
87
Type 1 RPGN
Goodpasture
88
Type 2 RPGN
Immunecomplex
PSGN
HSP
SLE
89
Steroids in HSP
Not useful for skin and renal lesions
Can be used for abdominal pain,arthralgia
90
Skin biopsy difference in HSP and cryoglobulinemia
HSP - IgA deposition
| Cryoglobulinemia- IgG and IgM
91
Most common glomerulonephritis worldwide
IgA nephropathy
92
IgA deposits in IgA nephropathy
Mesangial
93
IgA nephropathy
CLL
| HSP
94
Type 3 RPGN
Pauci immune
| ANCA associated
95
Biopsy finding in HSP
Vessel wall granulocytes
96
Cryoglobulinemia associated with RF
Type 2 and 3
97
Clonality in cryoglobulinemia
Type 1 monoclonal
Type 2 polyclonal
Type 3 both monoclonal and polyclonal
98
Cryoglobulinemia associated with malignancy
Type 1
99
Malignancies associated with cryoglobulinemia
MM
| Waldenstrom
100
Diseases associated with cryoglobulinemia
Hepatitis C
Sjogren
SLE
101
Screening for hepC
ARTHRALGIA
Palpable Purpura
Polyneuropathy
102
Renal involvement in cryoglobulinemia
Type 1 MPGN
103
Rheumatoid factor
IgM against IgG
104
HepC
Lichen planus
PCT(porphyria cutenea tarda)
Sjogren
Essential mixed cryoglobulinemia
105
C3 and C4 both decreased in
```
SLE nephritis
MPGN 1(C4 decrease out of proportion to C3 decrease)
```
106
Purpura in mixed cryoglobulinemia
Confluent Purpura
107
Hypersensitivity vasculitis
Cutaneous Leukocytoclastic angitis
Never involves kidney
108
Complement deficiency in SLE
C1q
C2
C4
Deficiency
109
Virus associated with SLE
EBV
110
SLE with worst prognosis
Class 4
111
SLE with least response to steroids
Class 5
112
Autoimmune hepatitis resembling lupus
Type 1
113
Which trimester abortions are common in lupus anticoagulant
Second
114
Most sensitive test in APLA
Lupus anticoagulant
Specific: anti cardiolipin antibodies
115
HLA protective in RA
```
HLA DR
1
5
7
9
```
116
Most common lung manifestation in RA
Plueritis with/without pleural effusion
Most dreaded: ILD
117
IL-6 antagonist
Tocilizumab
118
Principal symptom in sjogren
Dry mouth
119
Most common extra glandular symptom of sjogren
Arthralgia
120
IVIG use@
```
MG
MS
ITP
Kawasaki
GVHD
```
121
Lupus pernio is a sign of
Chronic disease
122
Neutrophilic vascular lesions seen
Behcet
123
CNS behecet
Brain parenchyma
Brain stem
Not spinal cord
124
Rx of Behcet
Thalidomide
125
Thrombophlebitis in Behcet
Both deep and superficial
126
Anti RO antibody in sjogren
Predicts duration of disease
127
Erythema marginatum never involves
Face
128
HLA associated with sjogren
HLA DR-3
129
Course of sarcoidosis
Most resolves spontaneously
130
Deposits in class 5
Sub epithelial
131
U1 RNP positivity is seen in
MCTD
High degree of chance of Pulmonary HT in limited scleroderma
132
Drug induced systemic sclerosis
Vinyl chloride
Penatzocin
Bleomycin
133
MC cause of death in systemic sclerosis
Lung involvement
134
Areas of vascular drop out seen in
Secondary raynaud associated with connective tissue disease
135
Earliest joint involved in RA
Small jts of UL
| MTP(among lower limb jts)
136
Felty syndrome occurs
Late in course of RA
137
Splenomegaly,neutropenia
T cell LGL
| Felty
138
Venules spared in
PAN
139
Large vessel vasculitis
GCA
Takayasu
Cogan
Behcet
140
Metabolic diseases where plasmapheresis is useful
Refsum
| Familial hypercholesterolemia
141
IVIG use
```
Dermatomyositis
MS
MG
Kawasaki
ITP
GVHD
GBS
```
142
Metabolic diseases where plasmapheresis is useful
Refsum
| Familial hypercholesterolemia
143
IVIG use
```
Dermatomyositis
MS
MG
Kawasaki
ITP
GVHD
GBS
```
