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From Flashcardlet > 7.5.2013(AIIMS) 8 > Flashcards

7.5.2013(AIIMS) 8 Flashcards

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0
Q

Most resistant phase of cell cycle to ionising radiation

A

Late S phase

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1
Q

Ionising radiation affects which stage of cell cycle the most

A

G2M transition

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2
Q

Most potent proton pump inhibitor

A

Lansoprazole

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3
Q

Peculiar adverse effect of PPI

A

Pseudomembraneous colitis

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4
Q

Markers of apoptosis

A

Annexin V
TUNEL
Cleaved caspases 3

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5
Q

Most characterestic feature of apoptosis

A

Chromatin condensation

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6
Q

Fixative used for trephine biopsy

A

Bouin fluid

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7
Q

Lebers hereditary optic neuropathy

A

Rapid optic nerve death

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8
Q

NARP

Leigh disease

A 
Neuropathy
Ataxia
Retinitis pigmentosa
Developmental delay
Mental retardation
Lactic incidemia
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9
Q

MELAS

A

Mitochondrial encephalomyopathy
Lactic acidosis
Stroke like episodes
May manifest only as diabetes

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10
Q

MERRF

A

Myoclonic epilepsy
Ragged red fibres
Ataxia
Sensorineural deafness

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11
Q

CPEO

A

Progressive external ophthalmoplegia

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12
Q

Pearson syndrome

A

Pancreatic insufficiency
Pancytopenia
Lactic acidosis

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13
Q

Kearns sayre syndrome

A

Progressive external ophthalmoplegia of early onset
Heart block
Retinal pigmentation

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14
Q

Diseases caused due to point mutations in mtDNA

A

Myoclonic epilepsy with ragged red fibres
Leber
MELAS

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15
Q

Mitochondrial diseases due to mutations involving nuclear DNA

A

Autosomal dominant or recessive inheritance
Leigh syndrome
Exertional myoglobinuria
Barth syndrome- infantile X linked cardioskeletal myopathy

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16
Q

Mitochondrial diseases caused due to deletions or duplications of mtDNA

A

CPEO

Kearns sayre syndrome

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17
Q

Markers for stem cells

A

CD34
Nestin
Beta 1 integrin for HSC

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18
Q

McLeod phenotype

A

Acanthocytosis

Decreased expression of kell antigen

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19
Q

Hereditary pyropoikilocytosis

A

Spectrin beta mutation

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20
Q

Grading of CAA

A

Vonsattel criteria

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21
Q

Major component in hirano bodies

A

Actin

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22
Q

Schmidt syndrome

A

Hashimoto thyroiditis

Lymphocytic adrenalitis

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23
Q

Trisomy due to mitotic non dysjunction

A

Trisomy 7

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24
Trisomies usually occur due to
Non dysjunction during meiosis 1
25
Non dysjunction due to meiosis 2
Trisomy 18
26
MPGN(11)
``` Hepatitis B Hepatitis C HIV Schistosomiasis Endocarditis Visceral abscess Infected ventriculoatrial shunt SLE Alpha1 anti trypsin deficiency CLL hereditary deficiency of complement regulatory proteins ```
27
FSGS(7)
``` HIV heroin Reflux nephropathy Hypertensive nephropathy Sickle cell anaemia Inherited : podocin,nephrin,alpha actinin4,TRPC6 Unilateral renal agenesis ```
28
Membranous glomerulopathy
``` Drugs(penicillamine,NSAID,gold) SLE hepatitis b and c,syphilis,schistosomiasis,malaria Carcinomas lung,colon,melanoma Autoimmune diseases ```
29
Congenital nephrotic syndrome
Finnish type NPHS1 Nephrin
30
Steroid resistant nephrotic syndrome
NPHS2 | Podocin
31
The following are found in normal brain/Alzheimer's Neuritic plaques Neurofibrillary tangles
Neuritic plaque are found in ageing brain
32
Normal MCHC with high MCV
Cobalamine deficiency
33
Microcytosis is seen before hypochromia in
Iron deficiency anaemia
34
Vitamin deficiency seen with omeprazole use
B12
35
Drugs causing Pseudomembraneous colitis(5)
``` Ampicillin Clindamycin Cefazolin Cephalexin PPI ```
36
Chronic use of PPI results in increased risk of
Bone fractures
37
Protein synthesis inhibitors are bacteriostatic except
Aminoglycosides
38
New drug used in the treatment of Pseudomembraneous colitis
Fidaxomycin
39
Drug indicated for depressive phase of maniac depressive psychosis
Lamotrigene
40
Adverse effects of clindamycin
``` Pseudomembraneous colitis SJS reversible elevation of liver enzymes Granulocytopenia Thrombocytopenia Inhibit NM transmission ```
41
Pseudo zero order kinetics(5)
``` Phenytoin Warfarin Theophylline Tolbutamide Aspirin ```
42
Which anti epileptic causes DIC
Lamotrigene
43
pneumococcal meningitis
Vancomycin + ceftriaxone
44
Meningococcal meningitis | Allergic to penicillin
Chloramphenicol
45
Listeria meningitis allergic to ampicillin
Co trimoxazole
46
Drug used to prevent cisplatin induced nephrotoxicity
Amifostine
47
Drug used to prevent xerostomia in radiation therapy
Amifostine
48
Drugs causing SLE
``` Clonazepam Hydralzine Isoniazid PAS Procainamide Sulphonamide CHIPS ```
49
Drugs causing methhemoglobinemia
``` Nitrites Nitrates Benzocaine Prilocaine Dapsone ```
50
Microsomal enzymes of bio transformation
CYP450 | Glucuronyl transferase
51
Longest acting penicillin
Benzathine penicillin
52
DOC choice in neurosyphilis
Procaine pencillin
53
Hypersensitivity to penicillin | All beta lactams are contraindicated except
Aztreonam( monobactam)
54
ESBL is sensitive to which beta lactams
Carbepenems
55
Acid resistant penicillins
``` Penicillin V Oxacillin Cloxacillin Dicloxacillin Amoxicillin Ampicillin ```
56
Penicillinase resistant penicillin
``` Oxacillin Dicloxacillin Cloxacillin Methicillin Nafcillin ```
57
Most common cause of resistance to penicillins
Alteration in penicillin binding protein
58
Most common ECG finding in bupivacaine toxicity
Broad QRS complexes with slow idioventricular rhythm
59
Anti epileptic causing megaloblastic anaemia
Barbiturates Phenytoin Primadone
60
Anti epileptic causing hypoprohrombinemia in newborns
Barbiturates
61
Nonarteretic ischemic optic neuropathy is seen in which vasodilator
Sildinafil
62
What colourblindness is seen in sildinafil and the reason?
Blue green | PDE6 inhibition
63
Mechanism of action of penicillin
Inhibits transpeptidase
64
ART causing hyper pigmentation of nails
Zidovudine
65
Peripheral neuropathy,pancreatitis seen in
Lamivudine | Stavudine
66
Maximum lactic acidosis seen in which ART
Stavudine
67
SJS is seen in which ART
Nevirapine
68
Which ART is contraindicated in pregnancy
Efavirenz
69
Which is reversible in amino glycoside toxicity Renal Hearing loss
Renal(PCT cells can regenerate )
70
Neuromuscular blockade due to aminoglycoside can be treated by
Ca++
71
cSSSI(complicated skin and skin structure infection) due to MRSA is treated by
Daptomycin Ceftaroline(5th generation cephalosporins ) Linezolid Tigecycline
72
Drug used for vancomycin resistant enterococci
Quinpristin dalfopristin
73
Streptogramins are bactericidal except against
VRE
74
``` Treatment of Primary Secondary Latent Syphilis Yaws Pinta ```
Benzathine pencillin
75
Fluroquinolone with longest half life
Sparfloxacin
76
Most common isoniazid toxicity in slow acetylators
Peripheral neuropathy
77
Greenish discolouration of urine is seen on treatment with
Nitazoxanide
78
Dose limiting side effect of thalidomide
Peripheral neuropathy

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