Prototype Drug Unit 1 & 2 Exam- Heloperidol (Hardol)

Question 1

What is the therapeutic classification of Haloperidol

Answer 1

Antipsychotic (first generation)

Question 2

What is the pharmacologic classificaiton of Haloperidol?

Answer 2

Nonphenothiazine, dopamine receptor antagonist

Question 3

What are the therapeutic effects and uses?

Answer 3

Used to treat acute and chronic psychotic disorders, tourette’s syndrome, persistent hiccups, autism, children with severe behavioral problems and OBS with psychotic features, and for the emergency sedation of severely agitated or delirious patients

Question 4

What is the mechanism of action?

Answer 4

Haloperidol depresses the cerebral cortex, hypotalamus, and limbic system of the brain which control activity and aggression. It blocks dopamine D2 receptors.

Question 5

What is the route?

Answer 5

PO, IM

Question 6

What is the absorption?

Answer 6

Variable PO; Well absorbed IM

Question 7

How is it distributed?

Answer 7

Widely distributed; may cross the placenta; secreted in breast mil and 92% bound to plasma protein

Question 8

How is it primarily metabolized?

Answer 8

Hepatically; significant first-pass metabolism

Question 9

How is it primarily excreted?

Answer 9

Renal; small amounts biliary with extensive enterohepatic recycling

Question 10

What are the adverse effects?

Answer 10

Drowsiness and EPS.

Question 11

What are the contraindications/precautions?

Answer 11

Do not give to people with Parkinson’s disease, seizure disorders, coma, alcoholism, severe mental depression, CNS depression, or lactation. Be cautious with people who have urinary retention, glaucoma, or severe cardiovascular disorders

Question 12

What are the drug interactions?

Answer 12

Interactions with drugs that affect CYP enzymes. Increased CNS depression can occur if given with other CNS depressants, including alcohol, TCAs or opioids. Do not take with lithium (can cause brain damage)

Question 13

What are the herbal/food interactions?

Answer 13

increased action of haloperidol can occur if chamomile, hops, kava, nutmeg, skullcap, or valerian are used with it. Antagonist action can occur if it is used with scopolia or jimsonweed.

Question 14

What is the pregnancy category?

Answer 14

C

Question 15

What is the treatment of overdose?

Answer 15

Supportive treatment. Antidysrhythmic and vasopressor drugs may be necessary to maintain cardiovascular function