Prototype Drug Unit 5 & 7- Fluconazole

Question 1

Therapeutic classification

Answer 1

Antifungal

Question 2

Pharmacologic classification

Answer 2

Inhibitor of fungal cell membrane synthesis, triazole

Question 3

Therapeutic effects and uses

Answer 3

Used to fight against Cindida albicans. Used to treat oropharyngeal candidiasis, esophageal candidasis, vulvovaginal candidiasis, and other systemic infections from this species.

Question 4

Mechanism of Action

Answer 4

Acts by interfering with the synthesis of ergosterol

Question 5

Adverse effects

Answer 5

Fever, chills, rash, dizziness, drowsiness, nausea, vomiting, diarrhea

Question 6

Contraindications

Answer 6

Hypersensitivity, be careful giving it to people with liver probs.

Question 7

Drug interactions

Answer 7

Warfarin can cause bleeding. Oral hypoglycemics like glyburide can cause hypoglycemia. Rifampin increases metabolism so dose of Fluconazole should be increased if taken with it. Erythromycin increases cardiotoxicity and possibly heart death