Prototype Drug Unit 3 & 4- Ondansetron

Question 1

Therapeutic classification

Answer 1

Antiemetic

Question 2

Pharmacologic classification

Answer 2

Serotonin receptor antagonist

Question 3

Therapeutic effects and uses

Answer 3

Used to prevent chemotherapy induced nausea and vomiting and is started 30 minutes before chemotherapy.

Question 4

Mechanism of action

Answer 4

Blocks serotonin receptors in the chemoreceptor trigger zone, an area of the brain responsible for nausea and vomiting

Question 5

Route

Answer 5

PO,IV

Question 6

Absorption

Answer 6

Rapidly absorbed

Question 7

Distributed

Answer 7

widely distributed; secreted in breast milk; over 70% bound to plasma proteins

Question 8

Primary metabolism

Answer 8

Extensive hepatic metabolism

Question 9

Primary excretion

Answer 9

Renal and feces

Question 10

Adverse effects

Answer 10

Headache, dizziness, drowsiness, and constipation or diarrhea

Question 11

Contraindications/precautions

Answer 11

Contraindications: Hypersensitivity

precautions: Cardiac abnormalities (It can cause dysrhythmias)

Question 12

Drug interactions

Answer 12

Inhibitors or inducers of the CYP450 enzyme can affect availability of ondansetron

Question 13

Pregnancy category

Answer 13

B