Prototype Drug Unit 5 & 7- Erythromycin

Question 1

Therapeutic classification

Answer 1

Antibacterial

Question 2

Pharmacologic classification

Answer 2

Bacterial protein synthesis inhibitor, macrolide

Question 3

Therapeutic effects and uses

Answer 3

Treatment and prophylaxis or susceptible bacterial infections. Used for patients who are allergic to penicillin or who have resistance to it.

Question 4

Mechanism of action

Answer 4

Inhibits bacterial production synthesis by binding to the 50s ribosomal subunit

Question 5

Adverse effects

Answer 5

Nausea, vomiting, diarrhea, abdominal cramping, dry skin, or burning.

Question 6

Contraindications

Answer 6

Hypersensitivity, be careful with patients that have impaired biliary or hepatic function because of the possibility of cholestatic hepatitis ( blocking in the bile ducts of the liver that causes inflammation)

Question 7

Drug interactions

Answer 7

Digoxin and warfarin can cause abnormal bleeding, don’t take with clindamycin, or chloramphenicol.

Question 8

Herbal/ food interactions

Answer 8

Grapefruit juice increases bioavailability