Prototype Drug Unit 8 & 9- Levothyroxine

Question 1

Classification

Answer 1

Thyroid hormone

Thyroid hormone replacement

Question 2

What is it used for?

Answer 2

Hypothyroidism

Question 3

Adverse effects

Answer 3

Tremors, headache, nervousness, or insomnia.

palpitations, tachycardia, angina, and cardiac arrest

Question 4

Contraindications

Answer 4

hypersensitivity, adrenal sufficiency, any heart problems (caution)

Question 5

Drug interactions

Answer 5

colestipol, calcium or aluminum antacids, sucralfate, and iron supplements= decrease absorption
pheytoin, caramazepine, rifampin, phenobarbital, and sertraline= increased metabolism
increases bleeding risk with warfarin
digoxin= decreases effectiveness

Question 6

Herbal/food interactions

Answer 6

soybean flower, cottenseed meal, walnuts, and dietary fiber= decreased absorption
Calcium or iron supplements should be take at least 4 hours after to prevent interference with drug absorption.
Strawberries, peaches, pears, cabbage, turnips, spinach, kale, brussels sprouts, radishes, and peas

Question 7

Treatment of overdose

Answer 7

circulating thyroid hormone with antithyroid drugs decreasing sympathetic stimulation with corticosteroid and beta-adrenergic blockers

Question 8

Important info

Answer 8

Start with low dosage and increase= effect can take 6-8 weeks
Take 1st thing in the morning