Prototype Drug Unit 3 & 4- Aluminum hydroxide

Question 1

Therapeutic classificaiton

Answer 1

Antiheartburn drug

Question 2

Pharmacologic classification

Answer 2

Antacid

Question 3

Therapeutic effects and uses

Answer 3

Can be combined with magnesium to increase their effectiveness of neutralizing the stomach acid and treat PUD and GERD

Question 4

Mechanism of action

Answer 4

Combines with gastric acid to produce aluminum chloride and water. This raises the pH of the stomach and inactivates pepsin.

Question 5

Route

Answer 5

PO

Question 6

Absorption

Answer 6

17-30% absorbed

Question 7

Distribution

Answer 7

Widely distributed

Question 8

Primary metabolism

Answer 8

Hepatic

Question 9

Primary excretion

Answer 9

Renal

Question 10

Adverse effects

Answer 10

Constipation, nausea

Question 11

Contraindications/precautions

Answer 11

patients who have low serum phosphate levels should not take it for long periods of time. Should not be used in patients with bowel obstruction

Question 12

Drug interactions

Answer 12

Don’t take with cimetidine, ciprofloxacin and other fluoroquinolones, digoxin, isoniazid, chlorioquid, NSAIDs, iron salts, phenyoin, tetracycline, and thyroxine.
Anticholinergics can increase the effects

Question 13

Herbal/food interactions

Answer 13

Inhibit the absorption of dietary iron

Question 14

Pregnancy category

Answer 14

C