Prototype Drug Unit 5 & 7- Celecoxib (Celebrex)

Question 1

Therapeutic classification

Answer 1

Anti-inflammatory

Question 2

Pharmacologic classification

Answer 2

COX-2 inhibitor, NSAID

Question 3

Therapeutic effects and uses

Answer 3

Used for moderate pain and inflammation associated with RA, osteoarthritis, dysmenorrhea, dental procedures, headache, and ankylosing spondyllitis. It is also an effective antipyretic agent

Question 4

Mechanism of action

Answer 4

Celecoxib selectively inhibits the enzyme COX-2. This reduces inflammation and relieves pain in the joints and smooth muscle tissue

Question 5

Adverse effects

Answer 5

back pain, peripheral edema, abdominal pain, dyspepsia, flatulence, dizziness, headache, insomnia, HTN

Question 6

Contraindications/Precautions

Answer 6

Hepatic insufficiency, advanced renal disease, anemia or in the postoperative phase of CABG, history of GI bleeding or PUD, don’t use with anticoagulants because it increases risk for bleeding

Question 7

Drug interactions

Answer 7

anticoagulants, alcohol, corticosteriods, aspirin, or other NSAIDs seriously affects GI.

Question 8

Herbal/food interactions

Answer 8

feverfew, garlic, ginger, ginkgo, horse chestnut, and red clover my increase risk of bleeding (pretty much the same as Ibuprofen)

Question 9

Treatment of overdose

Answer 9

Make them poop it out or throw it up