Prototype Drug Unit 5 & 7- Benztropine

Question 1

Therapeutic classification

Answer 1

Antiparkinson drug

Question 2

Pharmacologic classification

Answer 2

Cholinergic antagonist

Question 3

Therapeutic effects and uses

Answer 3

Used with trihexyphenidyl or levodopa/carbidopa to treat Parkinson’s disease.

Question 4

Mechanism of action

Answer 4

Reduces the excess cholinergic effect with dopamine deficiency and restores neurotransmitter balance

Question 5

Adverse effects

Answer 5

Nausea, constipation, dry mouth, blurred vision, drowsiness, dizziness, tachycardia, hypotension, nervousness

Question 6

Contraindications

Answer 6

closed-angle glaucoma, maysthenia gravis, tardive dyskinesia, GI or urinary obstruction, prostatic hypertorphy, peptic ulcer, tachycardia, and children under 3

Question 7

Drug interactions

Answer 7

other anticholinergic will create and additive effect. Alcohol and other CNS depressants will create an additive sedative effect. Antidiarrheals will slow GI motility and decrease absorption

Question 8

Herbal/food interactions

Answer 8

Kava decreases effect. Jimsonweed or butterbur increases effects

Question 9

Treatment of overdose

Answer 9

Physostigmine will reverse symptoms of anticholinergic intoxication.