Prototype Drug 5 & 7- Diazepam

Question 1

Therapeutic classfication

Answer 1

Antiepileptic drug, antianxiety drug, skeletal muscle relaxant

Question 2

Pharmacologic classification

Answer 2

Benzodiazepine, GABA receptor agonist

Question 3

Therapeutic effects and uses

Answer 3

Used for epilepticus, to prevent seizures in patient who have alcohol or benzodiazepine withdrawal. Also used for anxiety disorders.

Question 4

Mechanism of action

Answer 4

Enhances the action of GABA in the brain, which inhibits seizures

Question 5

Adverse effects

Answer 5

Sedation, headache, drowsiness, weakness, veritgo, ataxia, paradoxical excitement, short-term amnesia

Question 6

Contraindications

Answer 6

Depressed vital signs, shock, alcohol intoxiation, narrow-angle glaucoma. Be careful with patients who have depression, myasthenia gravis, liver or kidney probs, COPD. Don’t give it pregnant or lactating people unless its like really really needed.

Question 7

Herbal/food interactions

Answer 7

Kava and valerian= additive sedative effects
Echinacea lowers serum levels
Grapefruit juice decreases the peak of the drug

Question 8

Drug interactions

Answer 8

CNS depressants= intensify sedative effects
inatiparkinsonism meds worsen parkinson’s disease
Phenytoin increases toxicity
Don’t give withing 14 days of an MAOI

Question 9

Treatment of overdose

Answer 9

Benzodiazepien receptor antagonist to reverse the CBS depression