Adrenoreceptor Blockers Flashcards Preview

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Flashcards in Adrenoreceptor Blockers Deck (15):
0

Nonselective alpha blockers

Phenoxybenzamine
Phentolamine

1

Irreversible Alpha nonselective blocker (forms covalent bond with alpha receptors) (A1>A2)
Drug for pheochromocytoma
SE: orthostatic hypotension, reflex tachycardia

Phenoxybenzamine

2

Reversible alpha nonselective blocker (A1>A2)
Drug for rebound hypertension in Clonidine, pre surgical Pheochromocytoma, antidote for alpha1 agonist overdose
SE: Orthostatic hypotension, reflex tachycardia

Phentolamine

3

Alpha1 selective blocker
Drug for BPH
SE: first dose orthostatic hypotension, less chance for refelx tachycardia

Prazosin
(Doxazosin, Terazosin, Tamsulosin, Silodusin)
Tamsulosin is most selective for prostatic smooth muscle
Take at night to avoid orthostatic hypotension

4

Advantage of alpha1 selectivity

Reflex tachycardia is less common and less severe

5

Drug Class of Isoproterenol

Non Selective Beta AGONIST

I SOrry, kala ko Beta Blocker ka

6

Non selective beta blocker
Drug for HPN, Hyperthyroidism, angina prophylaxis
SE: Bronchospasm, erectile dysfunction
Masks initial symptoms of hypoglycemia (tachycardia, tremor, anxiety) in diabetics

Propranolol
(Pindolol, Timolol, Labetalol, Carvedilol, Nadolol)

7

Drugs with combined alpha and beta blockade
May be used for hypertension in Pheochromocytoma

Carvedilol
Labetalol

8

Side Effect of Beta blockers on DIabetics

Can mask premonitory symptoms of hypoglycemia (i.e. Tachycardia, tremor, anxiety)
Impaired hepatic mobilization of glucose

9

Beta agonists that are less likely to cause bronchospasm
(with intrinsic sympathomimetic activity)
Advantage in pxs with asthma

Pindolol
Acebutolol

ISA PA!

10

Side effects of beta blockers when used topically in the eye

Decreases protective reflexes
Increases risk for corneal ulceration

11

Beta Blockers with Absent Local Anesthetic activity

Timolol
Betaxolol

Treat Bulag

12

Beta blocker with longest half life

Nadolol

NAsa DOLO

13

Beta1 selective blocker
Drugs for HPN, Heart failure, SVT
SE: less likely to cause bronchospasm, erectile dysfunction
Masks initial symptoms of hypoglycemia (tachycardia, tremor, anxiety) in diabetics

Atenolol
(Betaxolol, Esmolol (SVT), Acebutolol, Metoprolol)

14

Beta blocker with the shortest half-life

Esmolol
ESMOL = small = shortest half life