Prostaglandin And Other Eikosanoids Flashcards Preview

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Flashcards in Prostaglandin And Other Eikosanoids Deck (15):
0

Eikosanoids are produced from?

Arachidonic acid

1

Cyclooxygenase ____:
Found in many tissues and are active in many physiologic processes

1

2

Cyclooxygenase ____:
Found primarily in inflammatory cells
Major role in tissue injury
Synthesis of prostacyclin and prostaglandin

2

3

These constitute the Slow-reacting substances of anaphylaxis

Leukotriene C4, D4

4

Prostaglandin that is protective of gastric mucosa and keeps PDA patent

E1

5

Prostaglandin that increases uterine tone, also maintains PDA

E2

6

Pulmonary prostaglandin

I2

7

Prostaglandin that decreases IOP, increases uterine tone

F2alpha

8

Prostaglandin for Platelet Aggregation

TXA2

9

Causes increased HCO3 and mucus secretion in the stomach, also causes uterine contraction
Drug for PUD, prevention of NSAID induced gastric mucosal injury
SE: miscarriage, Moebius sequence

Drug, Class

Misoprostol, Prostaglandin E1 analog
(Gemeprost)

10

Causes vascular smooth muscle relaxation and vasodilation
Drug for maintenance of PDA, erectile dysfunction
SE: priapism, light headedness

Drug, Class

Alprostadil, Prostaglandin E1 analog

11

Low concentrations contract, higher concentrations relax uterine and cervical smooth muscle
Drug for induction of labor, cervical ripening, abortifacient
SE: cramps, fetal trauma

Drug, Class

Dinoprostone, Prostaglandin E2 analog
(Sulprostone)

12

Activates FP receptors
For control of postpartum hemorrhage, abortifacient
SE: Vomiting, diarrhea, transient bronchoconstriction

Drug, Class

Carboprost, Prostaglandin F2alpha analog
(Bimatoprost, Travoprost, Unioprostone)

13

Causes vasodilation, reduces platelet aggregation
Drug for pulmonary HPN, reduces platelet aggregation in dialysis machines
SE: hypotension, flushing, headache

EPOprostenol (as in Erythropoeitin)
(Beraprost, Iloprost, Treprostinil)

14

Increases outflow of aqueous humor
Reduces IOP
Drug for glaucoma
Alters iris color, causing permanent eye color change

Latanoprost, Prostaglandin F2alpha analog
(Bimatoprost, Travoprost, Unoprostone)