Anti-Seizure Flashcards Preview

Pharmacology > Anti-Seizure > Flashcards

Flashcards in Anti-Seizure Deck (23):
0

Only anti-seizure drug that acts on K

Oxcarbazepine

1

Anti-seizure drugs that act on GABA alone

Diazepam
Clonazepam
Felbamate
Vigabatrin
Tiagabine

DI ma-CLOse ang Fly, VIG TIAn

2

Blocks voltage gated Na channels
Drug for GTC seizures, partial seizures DOC
SE: diplopia (dose-related), gingival hyperplasia, hirsutism, teratogen
CYP450 inducer
Zero Order Kinetics at high doses
Extensively protein bound

Phenytoin, Anticonvulsant (hydantoin)

LAHAT NG MAY -YDANTOIN

3

Blocks voltage gated Na channels and decreases glutamine release
Drug for GTC seizures, partial seizures DOC, trigrminal neuralgia
SE: diplopia (most severe idiosyncratic), ataxia (dose-related), blood dyscrasia, erythematous rash (most common idiosyncratic)
CYP450 inducer
Zero Order Kinetics at high doses
Extensively protein bound

Carbamazepine, Anticonvulsant (tricyclic)

4

Blocks high frequency firing of neurons modifies amino acid metabolism
Drug for GTC seizures, juvenile myoclonic epilepsy, DOC migraine, acute mania
SE: hepatotoxicity (in infants), teratogen (spina bifida), GI distress (most common)
CYP450 inhibitor

Valproic Acid, Anticonvulsant (branched chain FA)
(Sodium Valproate)

5

Increases duration of chloride channel opening
Long acting drug for seizure disorders (pedia), status epilepticus, hyperbilirubinemias (Gilbert's Syndrome)
SE: higher likelihood of dependence than benzodiazepines, acute intermittent porphyria
Additive CNS depression with alcohol
Potent inducer of CYP450
Safe for pregnant

Drug, Class

Phenobarbital
Primidone

Barbiturates

6

Decreases Ca2+ currents, T-type in thalamus
DOC for pure absence seizures
SE: GI distress

Drug, Class

Ethosuximide, anticonvulsant (cyclic ureide)

7

Increases frequency of chloride channel opening
DOC for Status epilepticus
SE: anterograde amnesia, unwanted daytime sedation
Additive CNS depression with alcohol

Drug?

Diazepam, anticonvulsant (barbiturate)

8

Increases frequency of chloride channel opening
Highly sedating for absence seizures
SE: anterograde amnesia, unwanted daytime sedation
Additive CNS depression with alcohol

Drug, Class

Clonazepam, anticonvulsant (benzodiazepine)

9

Blocks Ca2+ channels n-type
Drug for neuropathic pain (postherpetic neuralgia), Migraine
SE: dizziness, sedation, ataxia, nystagmus, tremor

Drug, Class

Gabapentin, Anticonvulsant (GABA derivative)
(Pregabalin)

10

Blocks Na and Ca channels, decreases glutamate
Drug for Bipolar disorder
SE: SJS

Drug, Class

Lamotrigine, Anticonvulsant (Phenyltriazine)

11

Selectively binds SV2A, modifies synaptic release of glutamate and GABA
Adjunct drug for GTC/Partial seizures, Juvenile Myoclonic Epilepsy
Not metabolized by Cytochrome P450

Levetiracetam, Anticonvulsant (piracetam)

12

Anticonvulsant with most number of MOA

Topiramate, Anticonvulsant (monosaccharide derivative)

13

Drug for Lennox-Gastaut Syndrome, GTC, Absence, Partial seizures, migraine prophylaxis
SE: psychomotor slowing, memory impairment, weightliss, acute myopia, glaucoma, urolithiasis

Topiramate, Anticonvulsant (monosaccharide derivative)

14

Drugs for GTC

Valproic Acid
Phenytoin
Carbamazepine

15

Drugs for Partial Seizures

Carbamazepine
Lamotrigine
Phenytoin

16

Drugs for Absence Seizures

Ethosuximide
Valproic Acid

17

Drugs for Myoclonic and Atypical Absence Syndromes

Valproic Acid

18

Drugs for Status Epilepticus

Lorazepam
Diazepam
Phenytoin
Phenobarbital

19

Drugs for Trigeminal Neuralgia

DOC Carbamazepine
Oxcarbazepine

20

Drugs for Neuropathic Pain

Gabapentin
Pregabalin

21

Drugs for Migraine

Gabapentin
Phenytoin
Topiramate
Valproic Acid

22

Drugs for Bipolar Affective Disorder

Valproic Acid (First-line)
Carbamazepine
Lamotrigine