Skeletal Muscle Relaxants Flashcards Preview

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Flashcards in Skeletal Muscle Relaxants Deck (19):
1

Blockade that results in neuromuscular paralysis from persistent depolarization, non-competitive antagonist

Depolarizing Blockade

2

Blockade that results in neuromuscular paralysis from pharmacologic antagonism, competitive antagonist

Non-depolarizing Blockade

3

Drugs eliminated in ______ have shorter action than kidney elimination

bile

4

Non-depolarizing Neuromuscular Block with the most rapid onset time

Rocuronium

5

Long acting neuromuscular blocker
SE: Respiratory paralysis, Ganglion block, Histamine release, Recurarization
Relatively contraindicated in myocardial ischemia

Tubocurarine, Non-depolarizing

6

Drug that reverses effects of Tubocurarine, Mivacurium, Atracurium

Neostigmine (Cholinesterase Inhibitor)

7

Short acting neuromuscular blocker
DOC for Myesthenia Gravis
SE: Respiratory paralysis, Moderate histamine release
Metabolized by pseudocholinesterase

Mivacurium, Non-depolarizing

8

Intermediate acting neuromuscular blocker
SE: Respiratory paralysis, histamine release, bronchospasm, seizures
Undergoes rapid spontaneous breakdown

Atracurium, Nondepolarizing
(Cistracurium - less adverse effects)

9

Neuromuscular blocker that undergoes Hoffmann Elimination

Atracurium
Cistracurium

10

Intermediate acting neuromuscular blocker
SE: Respiratory paralysis
Undergoes elimination in BILE
Muscle relaxation is potentiated by inhaled anesthetics, aminoglycosides, and quinidine

Vecuronium, Nondepolarizing

11

Intermediate acting neuromuscular blocker
SE: HYPERSENSITIVITY, Respiratory paralysis
Effects reversed by Neostigmine and novel drug SUGAMMADEX

Rocuronium, Nondepolarizing

12

Long acting neuromuscular blocker
Moderately blocks cardiac muscarinic receptors
Drug for euthanasia, lethal injection, Strychnine poisoning
SE: Respiratory paralysis, apnea, tachycardia, hypertension, recurarization
Reversed with Neostigmine

Pancuronium, Nondepolarizing

13

MOA of Strychnine

Glycine inhibitor
Similar to tetanus
Known convulsant

14

Drugs for Lethal Injection

Sedative: Thiopental (5g)
Relaxant: Pancuronium (100mg)
Arrhythmic: Potassium Chloride (100 mEq)

15

Identify Phase of Depolarizing Blockade: Transient fasciculations followed by flaccid paralysis

Phase I (Depolarization)

16

Identify PHase of Depolarizing Blockade:
Membrane repolarizes but receptor is desensitized to effects of ACh

Phase II (Depolarization)

17

Agonist at ACh-N receptors causing initial twitch then persistent depolarization
SE: Muscle pain, hyperkalemia, aspiration, malignant hyperthermia
Metabolized by pseudocholinesterase

Succinylcholine, Depolarizing

18

Interaction of Succinylcholine (possibly Tubocurarine) with inhaled anesthetics (Halothane) resulting in massive Calcium release from SR
Sx: Trismus

Malignant Hyperthermia

19

Tx of Malignant Hyperthermia

DOC Dantrolene
Rapid cooling of px