Antifungal Agents Flashcards Preview

Pharmacology > Antifungal Agents > Flashcards

Flashcards in Antifungal Agents Deck (13):
1

Drugs for Systemic Fungal Infections

Amphotericin B
Flucytosine
Ketoconazole
Fluconazole
Itraconazole
Caspofungin

2

Drugs for Superficial Mycoses

Griseofulvin
Terbinafin

3

Topical Drugs for Superficial Fungal Infections

Nystatin
Clotrimazole

4

Binds to ergosterol in fungal cell membranes, Fungicidal
Drug for systemic fungal infections
SE: Infusion reactions, RTA with magnesium and potassium wasting
Additive nephrotoxicity with aminoglycosides

Amphotericin B

5

Pyrimidine antimetabolite
Permease converted to 5-FU which inhibits Thimidylate Synthase, fungistatic
Selective toxicity due to low levels of permease and deaminase in mamallian cells

Flucytosine

6

Glucocorticoid synthesis inhibitor
Blocks ergosterol synthesis, fungistatic
Drug for Chronic mucocutaneous candidiasis, dermatophytosis
SE: Drug interactions, gynecomastia
Narrow antifungal spectrum
CYP450 INHIBITOR
Limited to topical use due to systemic toxicity

Ketoconazole

7

Inhibits ergosterol synthesis, fungistatic
Drug for Candidiasis, Coccidiomycosis, Cryptococcal meningitis (DOC)

Fluconazole

8

Inhibits ergosterol synthesis, fungistatic
Drug for blastomycosis, sporotrichosis, dermatophytosis, Alternative for infections due to aspergillus, coccidioides, cryptococcus and histoplasma
SE: rash, hepatotoxicity

Itraconazole

9

Echinocandin
Inhibits beta-glucan synthase, decreasing fungal cell wall synthesis, fungistatic
Drug for disseminated and mucocutaneous candidiasis, salvage therapy for invasive aspergillosis
SE: Flushing

Caspofungin
(Andulafungin, Micafungin)

LAHAT NG -FUNGIN

10

Interferes with microtubule function, inhibits synthesis and polymerization of nucleic acids, fungistatic
Drug for Dermatophytosis
SE: Disulfiram reaction, drug interactions
Accumulates in Keratin
CYP450 INDUCER
Contraindciated in porphyria

Griseofulvin

11

Inhibits Squalene Oxidase, fungicidal
Drug for Dermatophytosis, Onychomycosis
SE: Taste disturbances
Accumulates in keratin

Terbinafine

12

Polyene
Binds to ergosterols, fungicidal
Drug for candidiasis
SE: Nephrotoxicity
Minimal mucocutaneous absorption
Available as swish and swallow preparation

Nystatin

13

Azole
Inhibits ergosterol synthesis, fungistatic
Drug for mucocutaneous candidiasis, dermatophytosis, seborrheic dermatitis, pityriasis versicolor
Limited to topical use because of systemic toxicity

Clotrimazole