Drugs For Anemia And Hematopoeitic Growth Factors Flashcards

0
Q

Deficiency in _______ or _______ can cause megaloblastic anemia

A

Vitamin B12 or folic acid

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1
Q

Increased or Decreased in Iron Deficiency Anemia?
Iron
Ferritin
TIBC

A

Decreased
Decreased
Increased

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2
Q

Heavy metal chelator
Drug for acute Iron Toxicity
SE: ARDS, neurotoxicity, susceptibility to infections

A

Deferoxamine, Chelator

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3
Q

Tx for IDA

A

Ferrous Sulfate

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4
Q

Most common type of megaloblastic anemia

A

Pernicious anemia (defect in IF synthesis)

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5
Q

Drug with most amount of iron concentration

A

Ferrous Fumarate

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5
Q

Acute overdose of ferrous sulfate causes

A

Necrotizing gastroenteritis

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7
Q

Chronic iron overload can cause

A

Hemochromatosis

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8
Q

Triad of hemochromatosis

Occurs in pxs with abnormal iron absorption or frequent transfusions

A

Cirrhosis
DM
Hyperpigmentation

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9
Q

Tx for hemochromatosis

A
Phlebotomy
Chronic Deferoxamine (IV) or Deferasirox (IM)
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10
Q

Co factor in transfer of 1 carbon units, necessary step for DNA synthesis

Drug?

A

Vit B12

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11
Q

____________ deficiency causes neurologic effects

A

Vit B12

NOT FOLIC ACID

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12
Q

Neurologic effect of Vit B12 deficiency

A

Ataxic gait
Impaired position and vibratory sense
Spasticity

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13
Q

__________ deficiency: RBC production slows down

A

Vit B12

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14
Q

Hematoietic Growth Factor
Cofactor required to convert homocysteine to methionine, and metabolize methylmalonyl CoA
Drug for Vit B12 deficiency, megaloblastic anemia

A

Cyanocobalamin

Hydroxocobalamin

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15
Q

Required for normal DNA synthesis
Deficiency can cause NTD (Spina Bifida)

Drug?

A

Folic Acid

16
Q

Area of the GIT where Folic Acid is absorbed

A

Proximal jejunum

17
Q

Hematopoietic Growth Factor
Essential donor of methyl groups for synthesis of AA, purines and deoxynucleotide
Drug for megaloblastic anemia, prevention of coronary artery disease, prevention of NTD

A

Folic Acid (synthetic)
Folate (natural)
(Folacin, Folinic Acid)

18
Q
Agonist of Erythropoeitin receptors expressed by red cell progenitors
Drug associated with CKD
SE: pure red cell aplasia
HgB should be maintained <12g/dl
Prohibited as performance enhancing drug
A

Epoetin Alfa

LAHAT NG MAY EPO

19
Q

Myeloid growth factor
Accelerates neutrophil recovery and reduces incidence of infection
Drug for neutropenia associated with chemotherapy
SE: arthralgia, fever, edema

A

Granulocyte Colony Stimulating Factor (G-CSF)

LAHAT NG MAY -STIM

21
Q

Treatment of neutropenia and agranulocytosis

A

Filgrastim

22
Q

Megakaryocyte growth factor
Activate IL-11 receptors
Drug for prevention of chemotherapy induced thrombocytopenia
SE: pleural effusion, transient atrial arrhythmia

A

Oprelvekin

Thrombopoietin