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Flashcards in Alcohol Deck (21):
0

At higher doses, alcohol exhibits __________ order kinetics

Zero

1

Responsible for ethanol metabolism at blood levels higher than 100mg/dl

Microsomal Ethanol Oxidizing System (MEOS)

2

Inhibits aldehyde dehydrogenase

Disulfiram
Metronidazole
Oral hypoglycemics
Cephalosporin

3

Blood Alcohol Concentration?
Impaired Driving Ability

60-80 mg/dl

4

Blood Alcohol Concentration?
Emesis, Stupor

200-300 mg/dl

5

Blood Alcohol Concentration?
Coma

300-400 mg/dl

6

Blood Alcohol Concentration?
Death

>500 mg/dl

7

Ataxia
Confusion
Ophthalmoplegia

Disease?

Wernicke-Korsakoff Syndrome

weird ACO!

8

Tx for Wernicke Syndrome

Vitamin B1

9

Brain changes in Wernicke-Korsakoff Syndrome

Bilateral hemorrhagic necrosis of mamillary bodies

10

How much alcohol is modest consumption, raising HDL levels and protecting against CAD?

10-15 g/day

11

Hallucinations
Autonomic Disability - unstable vital signsz
Delirium
48-72 hours post discontinuation

Delirium Tremens

12

Tx for Alcohol Withdrawal Syndrome

DOC is long acting benzodiazepine
Diazepam, Chlordiazepoxide

Short acting benzodiazepine is preferred in pxs with compromized liver fxn

13

Drugs for Alcoholism

Naltrexone: Opioid receptor antagonists (cravings)
Acamprosate: NMDA receptor antagonist
Disulfiram: inhibits aldehyde dehydrogenase

14

Drugs with Disulfiram Reactions:
CHLOe PErsonally MAkes TEa PROduct METiculously

CHLOrpropamide
CefoPERazone
CefoMAndole
CefoTEtan
PROcarbazine
METronidazole

15

Drug that causes visual dysfunction, from commercial solvents, wood alcohol, windshield cleaners

Methanol

16

Tx for Methanol poisoning

Ethanol: competitive inhibitor of methanol
Fomepizole: inhibitor of Alc Dehydrogenase

17

Drug that causes renal damages and severe acidosis from industrial exposure
Damage is from accumulation of oxalic acid

Ethylene Glycol

18

Tx for Ethylene Glycol

Ethanol: competes for oxidation by Alc dehydrogenase
Fomepizole: slows or prevents formation of oxalic acid

19

Benzodiazepines

Midazolam
Lorazepam
Diazepam

20

Barbiturates

Thipental
Pentobarbital
Phenobarbital