Histamine, Serotonin, Ergot Alkaloids Flashcards Preview

Pharmacology > Histamine, Serotonin, Ergot Alkaloids > Flashcards

Flashcards in Histamine, Serotonin, Ergot Alkaloids Deck (19):
0

Most important amine autacoids

Histamine
Serotonin

1

Excess production of histamine is detectable in urine by measuring__________

Imidazole Acetic Acid

2

Classic triad of histamine effect

Wheal
Flush
Flare

3

H1 receptors: 2nd messenger

IP3, DAG increase

4

H2 receptors: 2nd messenger

cAMP, increase

5

H3 and H4 receptors: 2nd messenger

cAMP, decrease

6

First generation H1 receptor antagonist
Peripheral and CNS H1 receptors plus alpha and M receptor block
Drug for hypersensitivity, light sedation and motion sickness
SE: drowsiness

Diphenhydramine
(Chlorpheniramine, Cyclizine, Meclizine (motion sickness), Promethazine

7

Second generation H1 receptor antagonist
Blocks peripheral H1 receptors, no autonomic or anti-motion sickness effects
Interaction with Azoles/Erythromycin and Terfenadine/Astemizole can lead to fatal arrhythmia

Cetirizine
(Loratadine, Fexofenadine, Desloratadine, Terfenadine, Aztemizole)

8

Competitive pharmacologic block of H2
Reduction of gastric acid secretion
Drug for Peptic ulcer disease
SE: gynecomastia
CYP 450 Inhibitor

Cimetidine (only drug to cause gynecomastia)
(Ranitidine, Famotidine, Nizatidine)

9

Excess serotonin in the body can be detected by ___________ in the urine

5-hydroxyindole ascetic acid (5-HIAA)

10

What does HT in 5HT (Serotonin) stand for?

Hydroxytryptamine

11

5-HT3 receptor is found in ___________, an area in the brain associated with vomiting

Area postrema

12

5-HT1d/1b receptor agonist, causes vasoconstriction, modulates NT release
DOC for acute migraine (if still ongoing), cluster headache
SE: dizziness, vasospasm

Sumatriptan, Serotonergic Agent
(Almotriptan, Eletriptan, Frovatriptan, Naratriptan, Rizatriptan, Zolmitriptan)

LAHAT NG -TRIPTAN

13

5HT3 receptor antagonist
Pharmacologic antagonist for chemotherapy and post op vomiting
SE: QRS and QT prolongation (dolasetron), constipation (alosetron)

Ondansetron, Serotonergic Agent
(Granisetron, Dolasetron, Palonosetron, Alosetron)

LAHAT NG -SETRON

14

Produced from a fungus
Partial agonists at alpha adrenoreceptors and 5-HT receptors
VASOSELECTIVE, UTEROSELECTIVE, CNS SELECTIVE

Ergot Alkaloids

15

Produced from a fungus
Partial agonists at alpha adrenoreceptors and 5-HT receptors
VASOSELECTIVE, UTEROSELECTIVE, CNS SELECTIVE

Ergot Alkaloids

16

5HT2 receptor VASOSELECTIVE antagonist
Drug for migraine, cluster headache
SE: retroperitoneal fibrosis

Ergotamine, Ergot Alkaloids
(Dihydroergotamine, Methysergide)

17

Antidote for Ergotamine

Nitroprusside

18

5HT2 receptor URETEROSELECTIVE antagonist
Drug for post-partum bleeding
SE: Abortion

Ergonovine, Ergot Alkaloid
(Methylergonovine)