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Flashcards in Drugs For Asthma Deck (14):
0

IV corticosteroids are only used as relievers for this kind of asthma

Status Asthmaticus

1

Short acting beta 2 agonist
DOC for acute asthma
May precipitate arrhythmia in pxs with concurrent COPD and heart disease

Drug?

Albuterol/Salbutamol
(Levalbuterol, Terbutaline, Metaproterenol, Pirinuterol, Procaterol, Fenoterol)

2

Long acting beta 2 agonist
Drug for asthma prophylaxis and potentiation of corticosteroid action
Increases asthma mortality when used alone
May precipitate arrhythmia in pxs with concurrent COPD and heart disease
No role in acute attacks

Drug?

Salmeterol
(Formoterol, Cleneterol, Bambuterol)

3

Muscarinic receptor antagonist
Prevents vagal stimulated bronchoconstriction
Drug for asthma, COPD
SE: dry mouth
More effective and less toxic than Beta agonists in pxs with COPD

Drug?

Ipratropium
(Tiotropium)

4

Methylxanthine
Inhibits phosphodiesterase, adenosine receptor antagonist, causes bronchodilation
Drug for prophylaxis of nocturnal asthma attack
Narrow therapeutic window

Drug?

Theophylline
(Aminophylline, Pentoxyfylline: also for intermittent claudication)

LAHAT NG -YLLINE

5

Antidote for Theophylline overdosage

Class?

Beta-blockers

6

Mast cell stabilizer
Prevents degranulation
Drug for asthma prophylaxis
No bronchodilator action, no role in acute attacks

Drug?

Cromolyn sodium

7

Inhibitor of Phospholipase A2, reduces cyclooxegenase expression
DOC for asthma prophylaxis, COPD, allergic rhinitis
SE: oropharyngeal candidiasis, mild growth retardation

Drug?

Fluticasone
(Beclomethasone, Budesonide, Ciclesonide, Flunisolide, Mometasone, Triamcinolone)

8

Which corticosteroid is used for tx of Status Asthmaticus?

IV Hydrocortisone

9

Which corticosteroid has lowest systemic steroid toxicity?

Ciclesonide

10

Leukotriene synthesis inhibitor
Drug for asthma prophylaxis
SE: elevation of liver enzymes
No bronchodilator action

Drug?

Zileuton

11

Leukotriene antagonist
Drug for asthma prophylaxis
Rare SE: Churg-Strauss Syndrome
No bronchodilator action

Drug?

Montelukast
(Zafirlukast, Pranlukast)

12

Severe asthma with increased eosinophil count and eosinophilic deposits in the small vessels of the lungs

Disease?

Churg-Strauss Syndrome

13

Binds IgE antibodies on mast cells, reduces reaction to inhaled antigen
Drug for prophylaxis of severe, refractory asthma that is unresposive to all other drugs
EXPENSIVE!

Omalizumab, Monoclonal Antibody, Anti-IgE