Drugs for Parkinsonism Flashcards Preview

Pharmacology > Drugs for Parkinsonism > Flashcards

Flashcards in Drugs for Parkinsonism Deck (14):
1

Primary signs of Parkinson's Disease

It's a TRAP!
Tremor
Rigidity
Akinesia/Bradykinesia
Postural Instability

2

Drugs that can induce Parkinsonism

Typical Antipsychotics
Reserpine
Methylphenyltetrahydropyridine

3

Dopamine precursor and inhibitor of peripheral metabolism via Dopa decarboxylase
Primary drug for Parkinson's
SE: Emesis, dyskinesia, on-off phenomena, wearing-off phenomena
Contraindicated in pxs with history of psychosis
Hypertensive crisis occurs when used with MAOI

Levodopa-Carbidopa
Can cross BBB

4

Alternating periods of improved mobility and akinesia in Parkinson's

On-Off Phenomena

5

Deterioration of drug effect in between medication doses

Wearing-Off Phenomena

6

Partial agonist at D2 receptors in brain
Drug for Parkinson's, Levodopa intolerance, Hyperprolactinemia
SE: Erythromelalgia, pulmonary fibrosis

Bromocriptine
(Pergolide)
Bro 2

7

Rare burning pain & warmth on extremities

Bromocriptine
(Pergolide)

8

Partial agonist at D3 receptors in brain
Drug for Restless legs syndrome, Parkinson's disease
SE: Compulsive gambling, hypersexuality, overeating, uncontrolable tendency to fall asleep
Contraindicatedin pxs with active PUD, psychotic illness or recent MI

Pramipexole
(Ropinirole)

WEIRD TOXICITY

9

Partial agonist at D3 receptors, antagonist at 5HT and alpha adrenoceptors
Drug for off periods of Parkinson's
SE: Severe nausea, can be prevented by premedicating with Trimethobenzamide

Apomorphine

10

MAO Type B Inhibitor
Drug for Parkinson's
Combination with Meperidine causes agitation, delirium and death
Serotonin syndrome occurs when used with SSRIs

Selegiline
(Rasagiline)

11

COMT inhibitor
Blocks L-dopa metabolism by inhibiting Catechol-O-Methyltransferase in periphery and CNS (only Tolcapone), Prolongs response to Levodopa
Drug for Parkinson's
SE: Sleep Disturbance, Orange Urine, Hepatotoxicity (Tolcapone), Neuroleptic Malignant Syndrome, Rhabdomyolysis

Entacapone
(Tolcapone)

12

Antiviral
Antagonizes Adenosine A
Drug for Parkinson's Disease, Influenza
SE: Acute toxic psychosis, (Mottling in adults) Livedo reticularis, Peripheral Edema

Amantadine

13

Drugs that can cause Livedo Reticularis (Blue-Red Lacy pattern, like mottling)

AMAN reads fHM and GQ
Amantadine
Hydroxyurea
Minocycline
Gemcitabine
Quinidine

14

Anticholinergic
Drug for Parkinson's, EPS caused by anti-psychotics
SE: Atropine like effects
Exacerbates tardive dyskinesias that result from prolonged use of antipsychotic drugs

Benztropine
(Biperiden, Trihexyphenidyl)