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Flashcards in Drugs For Coagulation Disorders Deck (36):
0

Potent endothelium derived vasoconstrictor

Endothelin

1

ADP: Platelet________

Aggregation

2

TXA2: Platelet _______ and ___________

Activation and vasoconstriction

3

Serotonin: Platelet __________ and ___________

Aggregation and vasoconstriction

4

Anticoagulants

Heparin
Warfarin
Direct Thrombin Inhibitors

5

Thrombolytics

T-PA derivatives
Streptokinase

6

Antiplatelet drugs

Aspirin
Glycoprotein IIb/IIIa inhibitors
Clopidogrel
PDE/Adenosine uptake inhibitors

7

Drugs that facilitate clotting

Vit K
Antiplasmin drugs
Replacement factors

8

Nonselective irreversible cox 1 and 2 inhibitor
Inhibits platelet aggregation
Drug for ARTERIAL THROMBI (increased platelets vs. venous thrombi)

Drug?

Aspirin

LAHAT NG MAY -SAL- at -ATE

9

Toxic dose and lethal dose of Aspirin

Toxic 150mg/kg
Lethal 500 mg/kg

10

Drug associated with Reye Syndrome in children

Aspirin

11

Triad of Aspirin Hypersensitivity?

SAMTER TRIAD
Asthma
Aspirin sensitivity
Nasal polyps

12

Expected acid base abnormality in salicylate poisoning

Respiratory alkalosis with HAGMA

13

Presentation of aspirin toxicity in adults vs. children?

Adults: Respiratory Alkalosis + HAGMA
Children: Pure HAGMA

14

Inhibits platelet aggregation by interfering with GpIIB/IIIA binding
Drug used during PCI, adjunct to thrombolysis, ACS
Prevents vessel restenosis, reinfarction and death

Drug, class?

Abciximab, Antiplatelet
(Eprifibatide, Tirofiban)

15

Drug that irreversibly inhibits binding of ADP to platelet receptors reducing platelet aggregation
For prevention and treatment of ARTERIAL thrombosis
SE: bleeding
Additive effects with ASA

Clopidogrel
(Ticlopidine, Prasugrel)

16

Inhibits Phosphodiesterase III, inhibits platelet aggregation and causes vasodilation
Drug for intermitent claudication, prevention of thromboembolic complications of cardiac valve replacement, and secondary prevention of ischemic stroke (with aspirin)

Drug, class?

Dipyridamole, Anti-platelet
(Cilostazol)

Dipyridamole has little or no benefit by itself
Cilostazol is contraindicated in HF

17

Anticoagulants: Indirect Thrombin Inhibitors

heparin, enoxaparin (LMWH), lepirudin

18

Anticoagulants: Direct Thrombin Inhibitors

Coumarin derivatives (Warfarin)

19

route of administration:
Heparin:________
Warfarin:________

Heparin: IV
Warfarin: Oral

20

Speed of Onset:
Heparin:________
Warfarin:________

Heparin: rapid (mins)
Warfarin: slow (days)

20

Can this be given in Pregnancy?
Heparin:________
Warfarin:________

Heparin: Yes
Warfarin: No

21

Activates Antithrombin III
Drug for DVT, Pulmo Embo, MI
SE: Drug-induced Thrombocytopenia
Monitor PTT (Normal is 1.5-2.5)

Drug, Class

Heparin, Anticoagulant

22

Antidote for Heparin Toxicity

Protamine Sulfate

23

Potentiates effect of antithrombin III on Factor Xa (more selective), less effect on Thrombin
Drug for DVT, Pulmo Embo, MI
SE: less risk of thrombocytopenia
Does not require PTT monitoring

Drug, Class

Enoxaparin, Anticoagulant
(Fondaparinux, Tinzaparin, Danaparoid, Dalteparin)

Protamine is only partially effective in reversal of effects

24

Binds to Thrombin's active site and inhibits its enzymatic action
Drug for PErcutaneous Coronary Angiography (with ASA), HEparin-Induced Thrombocytopenia
Monitor with PTT
No reversal agents exist, use with caution in pxs with renal insufficiency

Drug, Class

Lepirudin, Anticoagulant
(Desirudin, Bivalirudin, Argatroban)

25

Inhibits Vit K epoxide reductase (Factor 2,7,9,10,ProteinC/S)
Drug for chronic anticoagulation, except in pregnancy
SE: bleeding, drug-induced skin necrosis (for pxs with protein c&s deficiencies)
Monitor PT

Drug, Class

Warfarin, Anticoagulant
(Dicumarol)

26

Antidote for Warfarin toxicity

Vitamin K (slow)
FFP (fast)
Discontinue drug

27

Anticoagulant with narrow therapeutic window
Active ingredient in most rat poisons

Warfarin

28

Why is an overlap of warfarin and heparin necessary?

Warfarin is initially prothrombotic and requires elimination of preformed clotting factors (8-60h)

29

Drug that partially reverses effects of LMWHs

Protamine Sulfate
Chemical antagonist of heparin

30

tPA analog converting plasminogen to plasmin, degrading fibrin and fibrinogen, causing thrombolysis
Drug for acute MI, Ischemic stroke, pulmonary embolism
SE: cerebral hemorrhage

Drug, Class

Alteplase, Thrombolytic
(STREPTOKINASE)

LAHAT NG MAY -PLASE/-KINASE

32

Loss of effectiveness on 2nd use and allergic reactions may be observed with this thrombolytic

Drug?

Streptokinase

33

Completely inhibits plasminogen activation
Drug for prevention of acute bleeding
Contraindicated in DIC and genitourinary bleeding
Antidote for Streptokinase Toxicity

Drug, Class

Aminocaproic Acid, Antiplasmin
(Tranexamic Acid)

34

Increases supply of reduced vitK
Drug for VitK deficiency, Warfarin antidote, prevents bleeding in newborns
SE: infusion reaction

Drug, Class

Vit K1 Phytonadione
Vit K2 Menaquinone
Vit K3 Menadione (never use in therapeutics, ineffective)

Endogenous vitamin

35

Vasopressin V2 agonist
Drug for Hemophilia A, vWD, Central DI
SE: Headaches, flushing, hyponatremia, seizures
Increases factor VIII activity of pxs with mild Hemophilia A or vWD

Drug?

Desmopressin