NSAIDs, Acetaminophen And Drugs For Gout Flashcards Preview

Pharmacology > NSAIDs, Acetaminophen And Drugs For Gout > Flashcards

Flashcards in NSAIDs, Acetaminophen And Drugs For Gout Deck (31):
0

Antiplatelet drug
Contraindicated in pxs with Gout because it prevents uric acid excretion
Nonselective IRREVERSIBLE COX1/2 inhibitor
Drug for prevention of ARTERIAL thrombosis and for inflammatory disorders
Uncoupler of Oxidative Phosphorylation

Aspirin

1

Aspirin dose <300mg/d is for?

Low: For platelet aggregation

2

Aspirin dose 300-2400mg/d is for?

Intermediate: Antipyretic and analgesic effects

3

Aspirin dose (2400-4000mg/d) is for?

High: Anti-inflammatory effects
Follows Zero Order Elimination (constant amount)

4

Toxic and Lethal dose of ASA

Toxic: 150mg/kg
Lethal: 500mg/kg

5

Tx for ASA Overdose (Weak acid)

Alkalinize Urine with HCO3
Supportive mgmt
Activated charcoal/gastric lavage

6

Non-selective REVERSIBLE COX1/2 inhibitor
Inhibits Prostaglandin synthesis
Drug for analgesia
SE: GI bleeding (less than ASA)
Long term use reduces risk for Colon CA

Drug, Class

Ibuprofen, NSAID nonselective

Marami pang iba

7

Non-selective REVERSIBLE COX1/2 inhibitor
Inhibits Prostaglandin synthesis
Drug for POST-SURGICAL analgesia
SE: high risk for GI toxicity and nephrotoxicity
Only IV NSAID

Drug

Ketorolac, NSAID nonselective

Restrict use to 72 hours only

8

Non-selective REVERSIBLE COX1/2 inhibitor
Inhibits Prostaglandin synthesis
Drug for closure of PDA
SE: serious hematologic reactions

Drug, Class

Indomethacin, NSAID nonselective

9

Selective COX2 inhibitor, inhibits prostaglandin synthesis
Drug for analgesia, anti-inflammatory
SE: reduced risk for GI bleeding

Drug

Celecoxib
(Etoricoxib, Parecoxib, Rofecoxib, Valdecoxib)

10

COX3 inhibitor, weak COX1 and COX2 inhibitor
Drug for analgesia, antipyretic
SE: hepatotoxicity (inc with alcohol overdose)
Preferred antipyretic in children, does not cause Reye Syndrome

Drug

Paracetamol
(Acetaminophen, Phenacetin)

11

Antidote for Paracetamol toxicity

N-acetylcysteine (sulfhydryl donor)

May do supportive management with gastric decontamination

12

Identify the Stage of Paracetamol Overdose:
Nausea/vomiting

Stage I: up to 24 hours

13

Identify the Stage of Paracetamol Overdose:
Hepatotoxicity

Stage II: 24-72 hours

14

Identify the Stage of Paracetamol Overdose:
ATN, HAGMA

Stage III: 72-96 hours

15

Identify the Stage of Paracetamol Overdose:
Recovery

Stage IV: 4 days to 2 weeks

16

Paracetamol:
Toxic Dose:________
Lethal Dose:________

Toxic: 150mg/kg (same as ASA)
Lethal: 15g

17

Inhibits AICAR transformylase
DMARD of choice for RA, chemotherapy
SE: mucosal ulcers, pseudolymphomatous reaction

Drug

Methotrexate

18

Rescue agent for MTX toxicity

Leucovorin (Folinic acid)

19

Binds to TNF-alpha to prevent binding
DMARD for Crohn's disease
SE: bacterial infections, reactivation of latent TB, lymphoma
Synergistic with MTX

Drug

Infliximab
(Adalimumab, Etanercept)

20

Forms 6-thioguanine
DMARD for RA
SE: bone marrow suppression, increased incidence of lymphoma
Cannot give with Allopurinol

Drug

Azarhioprine

21

Suppresses T-lymphocyte response to mitogens
DMARD for RA and malaria
SE: ocular toxicity

Drug

Chloroquine
(Hydroxychloroquine)

Safe in pregnant

22

Forms Phosphoramide mustard, crosslinking DNA to prevent replication
DMARD for RA, chemotherapy
SE: hemorrhagic cystitis

Drug

Cyclophosphamide

23

Inhibits IL1 and IL2 receptor production
DMARD for RA, tissue transplantation
SE: nephrotoxicity, gingival hyperplasia, hirsutism

Drug

Cyclosporine

24

Inhibits Inosine monophosphate dehydrogenase (impt in guanine nucleotide synthesis)
Inhibits T lymphocyte proliferation
Drug for SLE nephritis, RA
SE: reversible myelosuppression (neutropenia)

Drug

Mycophenolate Mofetil

25

Inhibits inflammatory cytokines
DMARD for RA, inflammatory bowel disease
SE: hemolytic anemia, methemoglobinemia, reversible infertility in men

Drug

Sulfasalazine

26

Inhibits microtubule assembly
Drug for gout, Familial Mediterranean Fever
SE: diarrhea, hepatic necrosis, ARF, agranulocytosis

Drug

Colchicine

27

NSAID used as initial treatment of gout as Colchicine replacement

Indomethacin

28

Competes with Uric Acid for reabsorption in the proximal tubules
Drug for gout
SI: GI irritation, aplastic anemia
May precipitate acute gout during early phase and inhibits secretion of other weak acids

Drug?

Probenecid
(Sulfinpyrazone)

29

Irreversible Xanthine Oxidase inhibitor
First line tx for Gout, tumor lysis syndrome
SI: cataracts
Witheld 1-2 wks after acute gouty arthritis
Inh metabolism of mercaptopurine and azathioprine

Drug?

Allopurinol

30

Reversible xanthine oxidase inhibitor
More selective
Drug for chronic gout, tumor lysis syndrome
Witheld for 1-2 weeks after acute gouty arthritis

Drug?

Febuxostat