Local Anesthetics Flashcards Preview

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Flashcards in Local Anesthetics Deck (19):
1

Identify:
Esters

TetracaIne
ProcaIne
BenzocaIne

Esters have only one I in their names

2

Identify:
Amide

Bupivacaine
Ropivacaine
Lidocaine

Amides have 2 I's in their names

3

Local anesthetic with the shortest half life

Procaine 1-2mins

4

Local anesthetic with the longest half life

Ropivacaine 4.2 hrs

5

Why should you not inject lidocaine into an abscess

Abscess is acidic; if below pKa = charged form will predominate, drug will be ineffective

6

All local anesthetics are vasodilators except:

Cocaine

7

Most important toxic effect of local anesthetics

CNS: Seizures
Cardiotoxicity: Arrhythmia

8

MOA of Cocaine

blocks catecholamine reuptake, intrinsic sympathomimetic activity

9

Blocks Na channel
Drug of extravasation complications from venipuncture, inadvertent intraarterial injections
SE: Antibody formtion
Shortest half life among local anesthetics

Drug, Class

Procaine, Local anesthetic (ester)
(Novocaine)

10

Blocks Na channel
Drug of Topical anesthesia
SE: Skin irritation, antibody formation, CNS and Cardiac effects
Shortest half life among local anesthetics

Drug, Class

Benzolamine, Local anesthetic (ester)
(Butamben)

11

Blocks Na channel, intrinsic sympathomimetic activity. Vasoconstriction
Drug for Topical anesthesia (very effective)
SE: Antibody formation, abuse liability, severe HPN, cerebral hemorrhage, cardiac arrhythmia, MI

Drug, Class

Cocaine, Local anesthetic (ester)
Drug of abuse

12

Blocks Na channel
Drug for spinal anesthesia, Epidural anesthesia, topical ophthalmic anesthesia
SE: Antibody formation, CNS and Heart effects

Drug, Class

Tetracaine, Local anesthetic (ester)

13

Blocks Na channel
Drug for arrhytmia
SE: Seizures, CNS and Heart effects
Shortest half life among local anesthetics

Drug, Class

Lidocaine, Local anesthetic (amide)

14

Toxic Dose of Lidocaine

5mg/kg

15

Solution Concentration? How many mg in ml

10mg/mL

16

Blocks Na channel
Drug for Dental Anesthesia
SE: Methemoglobinemia (Fe in 3+)

Drug, Class

Prilocaine, Local Anesthetic (amide)

17

Blocks Na channels
Drugs for Epidural anesthesia, intrathecal anesthesia
SE: Severe cardiovascular toxicity, HPN, arrhythmia
Use with caution in pregnant

Bupivacaine, Local Anesthetic (amide)

18

Blockade of Na channels slows
Drug for Epidural anesthesia
SE: Cardiotoxicity

Ropivacaine

19

Longest half-life among local anesthetics

Ropivacaine