Antimycobacterial Drugs Flashcards Preview

Pharmacology > Antimycobacterial Drugs > Flashcards

Flashcards in Antimycobacterial Drugs Deck (18):
1

Nicotinic acid derivative
Inhibits mycolic acid synthesis, bactericidal
Drug for TB
SE: Neurotoxicity, hepatitis, drug-induced Lupus
Potent CYP450 inhibitor

Isoniazid

2

Most important drug for TB

Isoniazid

3

Prevent neurotoxicity in Isoniazid by giving

Pyridoxine
Vit B6

4

Inhibits DNA dependent RNA polymerase, bactericidal
Drug for TB (Active, latent), leprosy, meningococcal and staphylococcal carrier states
SE: Red orange urine, hepatotoxicity, flu like syndrome
Potent CYP450 INDUCER
Delays resistance to dapsone

Rifampicin

Don't be confused with RNA-Dependent DNA Polymerase (HIV DRUGS)

RNA polymerase inhibitor
Red Orange body fluids
Rapid development of resistance
Revs up Cytochrome P450

5

Inhibits RNA-Dependent DNA Polymerase

HIV Drugs

Don't be confused with DNA-dependent RNA polymerase (Rifampicin)

6

Butanol derivative
Acts on mycobacterial cell wall, bacteriostatic
Drug for active TB
SE: Visual disturbances, red-green color blindness, retrobulbar neuritis, retinal damage
Perform baseline ophthalmologic exam before starting antimycobacterial therapy

Ethambutol

EYE
No liver toxicity

7

Bacteriostatic but can be bacteriocidal on actively dividing mycobacteria
Drug for active TB
SE: Hepatotoxicity, Hyperuricemia
Also known as sterilizing agent
MOST HEPATOTOXIC TB Drug

Pyrazinamide

8

Which anti-TB drugs are hepatotoxic?

Iso a Red Pyre!
Isoniazid

9

Drug for streptomycin resistant TB

Amikacin

10

Drug for TB resistant to first line drugs

Ciprofloxacin
Ofloxacin

11

Drug with no cross resistance with INH

Ethionamide

12

Drug rarely used in TB because primary resistance is common

P-Aminosalicylic Acid (PAS)

13

Alternative Anti-TB drug
SE: Ototoxicity

Capreomycin

14

Alternative Anti-TB drug
SE: Peripheral Neuropathy

Cycloserine

15

Inhibits Folic Acid Synthesis, bacteriostatic
Drug for leprosy, backup for PCP Pneumonia
SE: Methemoglobinemia
Most active drug against M. Leprae
Ususally in combination with Rifampicin and Cofazimine

Dapsone

16

Phenazine dye
Binds to guanine bases in bacterial GNA, bactericidal
Drug for leprosy (sulfone resistance)
SE: Skin discoloration, red-brown discoloration of breast milk
Discontinued in the US

Colfazimine

17

Drug for atypical mycobacteria prophylaxis

Clarithromycin
Azithromycin
With or without rifabutin (For M. Avium Complex in HIV) in pxs with CD4<50/L

18

Tx for Atypical mycobacteria

Azithromycin/Clarithromycin + Ethambutol AND Rifabutin