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Flashcards in Drugs of Abuse Deck (36):
1

Define: Compulsive Drug-using behavior

Addiction

2

Define: Decreased response to a drug

Tolerance

3

Identify Etiology of tolerance:
increased disposition of the drug

Metabolic Tolerance

4

Identify Etiology of tolerance:
ability to compensate for the effects of a drug

Behavioral Tolerance

5

Identify Etiology of tolerance:
Changes in receptor or effector systems involved in drug actions

Functional Tolerance

6

Abstinence syndrome is also known as

Withdrawal syndrome

7

Dopamine in the __________ of the brain appears to play a role in reward.

Mesolimbic System

Excess dopamine stimulation may lead to pathologic reinforcement

8

Enumerate: Amphetamines

Detroamphetamine
Metamphetamine

9

Identify Drug:
Feeling of euphoria and self-confidence
In chronic high dose, can lead to psychotic state, necrotizing arteritis (leading to cerebral hemorrhage and renal failure)

Amphetamines

10

Pathophysiology of Amphetamine Overdose

Increased release of catecholamines

11

Tx for Amphetamine overdose

No antidote
Control body temp
Protect against cardiac arrhythmia and seizures

12

Pathophysiology of Amphetamine Withdrawal

It's like from overdrive to crashing

13

Tx for Amphetamine withdrawal

Antidepressants (amineptin, mirtazapine) are of limited benefit
Acidify urine to increase elimination

14

Similar drugs to Amphetamines
(Congeners)

DOM
MDA
MDMA (Ecstasy)

15

Effects of Similar drugs to Amphetamines (Congeners)

more selective action on serotonin transporters
facilitate interpersonal communication
acts as sexual enhancers
depletion of neurons in serotonergic tracts

16

Sx of MDMA Overdose

Profound hyponatremia
Serotonin Syndrome
Heart
Kidney
CNS

17

Tx for MDMA Overdose

Supportive care (control seizures, hyperthermia, and serotonin syndrome)
Fluid resuscitation with HYPERTONIC SALINE for hyponatremia

18

Cocaine has similar effects to this drug

Amphetamine

19

Effects of Cocaine

Short-lasting euphoria, self confidence and mental alertness

20

Sx of Cocaine Overdose

Mydriasis (Nakakita ka ng Coke, nanlaki mata mo)
Crack Lung (Hemorrhagic Alveolitis)

21

Tx for Cocaine Overdose

No specific antidote
Supportive care

22

When used in pregnancy, this drug is associated with increased fetal morbidity and mortality

Cocaine

23

Sx of Cocaine withdrawal: Stimulating/Depressive?

Depressive

24

Tx for Cocaine Withdrawal

Antidepressant drugs may be incidated

25

Infants born to mothers who abused this drug can have Cystic Cortical Lesions

Cocaine

26

Enumerate Phencyclidine Agents

Phencyclidine
Ketamine

27

Effects of Phencyclidine

Antagonists of Glutamate NMDA
No actions on Dopa neurons in the CNS

28

Most dangerous hallucinogenic agent

PCP
(Psychomimetic)

29

Sx of Phencyclidine Overdose

Horizontal and Vertical Nystagmus
Fatal Seizures

30

Tx for Phencyclidine Overdose

Parenteral benzodiazepines (Diazepam, Lorazepam) to curb excitation and protect against seizures

31

Enumerate Miscellaneous HALLUCINOGENIC Agents

LSD
Mescaline
Psilocybin

32

Effects of Hallucinogenic Agents

Psychedelic and mind ravelling effects
Marked somatic effects
Panic reactions

33

Active ingredient in Marijuana

Tetrahydrocannabinol (THC)

34

More potent and partially purified Marijuana is called

Hashish

35

Effects of Marijuana are potentiated by concomitant use of _____________ like ethanol

Class?

Sedative - Hypnotics

36

Effects of marijuana

Dream like state
Vasodilation
Tachycardia
Reddened conjunctiva (Bloody Mari(juana) = Red)
Dry mouth
(ANTICHOLINERGIC! Like atropine)