Antiarrhythmics Flashcards
(30 cards)
Class 2 acts on what phase of cardiac action potential
Phase 4
Beta blockers
Prolongs PR interval
Class 3 acts on what phase of cardiac action potential
Phase 3
K channel blockers
Prolongs QT interval
Class 4 acts on what phase of cardiac action potential
Phase 2
CCBs
Prolongs PR interval
Class 1A antiarrhythmics
Prolongs AP duration
Procainamide
Disopyramide
Quinidine
Class 1B antiarrhythmics
shortens AP duration
Lidocaine
Mexiletine
Tocainide
Phenytoin
Class 1C antiarrhythmics
Flecainide
Propafenone
Encainide
Moricizine
Class 2 antiarrhythmics
Propranolol
Esmolol
Class 3 antiarrhythmics
Dofetilide
Sotalol
Amiodarone
Class 4 antiarrhythmics
Verapamil
Diltiazem
Miscellaneous antiarrhythmics
Adenosine
Causes lupus-like syndrome
Procainamide
Has marked antimuscarinic effects
Disopyramide
Cause cinchonism (headache, vertigo, tinnitus) and ITP
Quinidine
Treatment of class 1A overdose
Na lactate
DOC for ventricular arrhythmias post-MI; used for digoxin-induced arrhythmias
Class 1B
Used in neuropathic pain
Mexiletine
Causes agranulocytosis
Tocainide
Drugs that cause agranulocytosis
CCCAPPIT Clozapine Cotrimoxazole Colchicine Aminopyrine Phenylbutazone PTU Indomethacin Tocainide
Used for refractory arrhythmias; contraindicated for post-MI arrhythmias
Flecainide
Post-MI prophylaxis against sudden death; used for thyrotoxicosis
Propranolol
Used for acute perioperative and thyrotoxic arrhythmias; used in SVT
Esmolol
Treatment and prophylaxis of atrial fibrillation; causes torsades de pointes
Dofetilide
Indication for sotalol
Afib
SVT
Used for refractory arrhythmias; most efficacious of all antiarrhythmics
Amiodarone
