Nucleic Acid Synthesis Inhibitors Flashcards Preview

Pharmacology > Nucleic Acid Synthesis Inhibitors > Flashcards

Flashcards in Nucleic Acid Synthesis Inhibitors Deck (33)
1

Weakly acidic; Have a nucleus that resembles p-aminobenzoic acid (PABA)

Sulfonamides

2

Short-acting sulfonamide

Sulfisoxazole

3

Intermediate-acting sulfonamide

Sulfamethoxazole

4

Long-acting sulfonamides

Sulfadoxine

5

Weak base; structurally similar to folic acid; reaches high concentration in prostatic and vaginal fluids

Trimethoprim

6

MOA of sulfonamides

Bacteriostatic inhibitor of folic acid synthesis and competitive inhibitors of dihydropteroate synthase

7

MOA of trimethoprim and pyrimethamine

Selective inhibitor of dihydrofolate reductase

8

Sulfonamide used in burn infections

Silver sulfadiazine
Mafenide acetate

9

Components of Co-trimoxazole

Sulfamethoxazole
Trimethoprim

10

Antibiotic contraindicated in G6PD

Sulfonamides

11

Hypersensitive spectrum of sulfonamides

EM, SJS/TEN, PAN, exfoliative dermatitis

12

MOA of fluoroquinolones

Inhibits DNA gyrase (topoisomerase II) in gram negatives --> blocks relaxation of supercoiled DNA
Inhibits topoisomerase IV in gram positives

13

1st gen fluoroquinolones

Nalidixic acid
Cinaxacin
Rosoxacin

14

2nd gen fluoroquinolones

Ciprofloxacin
Ofloxacin
Norfloxacin

15

3rd gen fluoroquinolones (respiratory quinolones)

Levofloxacin
Sparfloxacin
Grepafloxacin

16

4th gen fluoroquinolones

Moxifloxacin
Trovafloxacin
Gemifloxacin
Gatifloxacin

17

Antimicrobial spectrum of 1st gen fluoroquinolones

UTI

18

Antimicrobial spectrum of 2nd gen fluoroquinolones

Gram negatives
Gonococci
Gram positive cocci
Streptococci
Mycoplasma

19

Antimicrobial spectrum of 3rd gen fluoroquinolones

Less gram negative
More gram positive
Streptococci
Enterococci

20

Antimicrobial spectrum of 4th gen fluoroquinolones

Broad spectrum
Anaerobes

21

Causes tendinitis and tendon rupture

Qui-Ten
Quinolones
Tendon rupture

Ciprofloxacin

22

Avoid giving fluroquinolones to?

Young children and pregnant women

23

Fluroquinolones enhance the toxicity of?

Theophylline

24

Antimetabolites

Sulfonamides
Trimethoprim
TMP-SMX

25

Used for the prevention and treatment of toxoplasmosis in the AIDS patient

TMP-SMX

26

DOC for traveler's diarrhea:
E. coli
Shigella
Salmonella

CONTRA
CON
TRAveler's diarrhea


Second generation quinolones:
Ciprofloxacin
Ofloxacin
Norfloxacin

27

A drug which can be used for gonorrhea and chlamydial urethritis

Ciprofloxacin (resistance is common);
TMP-SMX

28

DOC for ulcerative colitis

Sulfasalazine

29

Most common adverse effect of sulfonamides

Skin rash caused by hypersensitivity

30

DOC for nocardiosis

Sulfadiazine
TMP-SMX

31

Prophylactic against pneumocystis pneumonia in the AIDS patient

Sulfadiazine + pyrimethamine

32

Quinolones should not be used in children younger than?

10 years old (they may damage growing cartilage)

33

DOC for atypical pneumonia

Quinolones