Drugs Used In Coagulation Disorders Flashcards Preview

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Flashcards in Drugs Used In Coagulation Disorders Deck (46)
1

Antiaggregants

PGI-2
cAMP
Adenosine

2

Causes vasoconstriction (hemostasis)

TXA2
Endothelin

3

Clotting factors involved in intrinsic pathway

5
8
9
10
11
12
Prothrombin
Fibrinogen

4

Clotting factors involved in extrinsic pathway

5
7
10
Prothrombin
Fibrinogen

5

Used for the treatment of venous thromboses

Heparin
Warfarin

6

Used for the treatment of arterial thromboses

Antiplatelets

7

MOA of aspirin

Nonselective, irreversible COX inhibitor

8

Prophylaxis of choice for the prevention of arterial thrombosis

Aspirin

9

Toxic dose of aspirin

150mg/kg

10

Lethal dose of aspirin

500mg/kg

11

Triad of aspirin hypersensitivity

SAMTER TRIAD
Asthma
Aspirin sensitivity
Nasal polyps

12

Expected acid-base abnormality in salicylate poisoning

Respiratory alkalosis with HAGMA

13

Glycoprotein IIb/IIIa inhibitors

Abciximab
Eptifibatide
Tirofiban

14

ADP inhibitors

Clopidogrel
Ticlopidine
Prasugel

15

PDE III inhibitors

Dipyridamole
Cilostazole

16

Anticoagulants

Heparin
Direct thrombin inhibitor
Warfarin

17

Function of antithrombin III

Inactivates thrombin and factor Xa

18

Used during PCI to prevent thrombosis

GP IIb/IIIa inhibitors (inhibits platelet aggregation

19

Used for the prevention of restenosis after PCI

ADP inhibitors (reduces platelet aggregation)

20

Causes TTP

Ticlopidine

21

Used for the prevention of thromboembolic complications of cardiac valve replacement

PDE III inhibitors

22

Used for the management of intermittent claudication

Cilostazol

23

Cilostazol is contraindicated in patients with?

Heart failure

24

2 major types of anticoagulants

Indirect thrombin inhibitors
Direct thrombin inhibitors

25

Indirect thrombin inhibitors

Heparin
Enoxaparin (LMWH)
Lepirudin

26

Direct thrombin inhibitors

Coumarin derivatives (warfarin)

27

Anticoagulant of choice in pregnancy

Heparin

28

MOA of heparin

Activates antithrombin III

29

Antidote for heparin toxicity

Protamine sulfate

30

LMWHs

Enoxaparin
Dalteparin
Tinzaparin
Danaparoid
Fondaparinux

31

MOA of LMWH

Binds and potentiates effect of antithrombin III on factor Xa (more selective); less effect on thrombin

32

Does not require aPTT monitoring

LMWH

33

MOA of lepirudin

Binds to thrombin's active site and inhibits its enzymatic action

34

Anticoagulant of choice in patients with HIT

Lepirudin
Desirudin
Bivalirudin
Argatroban

35

MOA of warfarin

Inhibits vitamin K epoxide reductase

36

Used for chronic anticoagulation (DVT, afib, valve replacement) except in pregnancy

Warfarin

37

Antidote for warfarin toxicity

Vitamin K (slow)
FFP (fast)

38

Effect of CP450 inducers on warfarin

Reduce anticoagulant effect

39

Effect of CP450 inhibitors on warfarin

Increase anticoagulant effect

40

Fibrinolytic drugs are used mainly for the treatment of?

Acute MI
Ischemic stroke
Massive pulmo embo

41

tPA analogs (covert plasminogen to plasmin)

Alteplase
Anistreplase
Reteplase
Streptokinase
Tenecteplase
Urokinase

42

Antidote for tPA analog toxicity

Aminocaproic acid

43

MOA of aminocaproic acid and tranexamic acid

Competitively inhibits plasminogen activation

44

Aminocaproic acid and tranexamic acid are contraindicated in?

DIC
GU bleeding

45

Used for hemophilia A, vWF disease, and Central DI

Demopressin

46

Proaggregants

TXA2
5-HT
ADP