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Flashcards in Drugs Used In TB Deck (31)
1

MOA of ethambutol

Inhibits arabinosyl transferases involved in the synthesis of arabinogalactan in mycobacterial cell wall

2

MOA of pyrazinamide

Unknown
Converted to pyrazinoic acid under acidic conditions of macrophage lysosomes

3

MOA of streptomycin

Inhibits protein synthesis by binding to 30s subunit;
Binds to S12 ribosomal subunit inhibiting protein synthesis

4

Hepatotoxic anti-TB drugs

ISO a Red PYRe
Isoniazid

5

Contraindicated in G6PD
Causes drug-induced lupus
Neurotoxic

Isoniazid

6

Most important drug used in TB

Isoniazid

7

Potent CYP450 inhibitor

Isoniazid

8

Causes red-orange urine

Rifampicin

9

Causes red-green color blindness, retrobulbar neuritis, and color blindness

Ethambutol

10

Causes hyperuricemia

Ethambutol
Pyrazinamide

11

Causes nongouty polyarthralgia and porphyria

Pyrazinamide

12

Also known as sterilizing agent

Pyrazinamide

13

Treatment for category I

2 HRZE
4 HR

14

Treatment for category II

2 HRZES and 1 HRZE
5 HR

15

Category III

2 HRZ
4 HR

16

What is MDRTB?

Resistance to at least isoniazid and rifampicin

17

What is XDRTB?

Resistance to isoniazid, rifampin, plus any fluroquinolone and atleast one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin)

18

MOA of isoniazid

Inhibits mycolic acid synthesis

19

Potent CYP450 inducer

Rifampicin

20

MOA of rifampicin

Inhibits DNA-dependent RNA polymerase

20

Isoniazid inhibits the metabolism of what drugs?

Warfarin
Carbamazepine
Phenytoin

21

Causes hemolysis in G6PD deficiency

Isoniazid

22

Bacteriostatic anti-TB drugs

Ethambutol
Pyrazinamide

23

The active form of pyrazinamide is?

Pyrazoic acid

24

Requires bioactivation

Isoniazid
Pyrazinamide

25

Causes porphyria

Pyrazinamide

26

Causes hyperuricemia

Pyrazinamide
Ethambutol

27

Causes cholestasis

Rifampicin

28

Avoided in pregnancy

Pyrazinamide

30

Mechanism of resistance to ethambutol

Mutations in the emb gene

31

Causes flu-like syndrome with intermittent dosing

Rifampicin