Drugs Used In Coagulation Disorders

Question 1

Antiaggregants

Answer 1

PGI-2
cAMP
Adenosine

Question 2

Causes vasoconstriction (hemostasis)

Answer 2

TXA2

Endothelin

Question 3

Clotting factors involved in intrinsic pathway

Answer 3

5
8
9
10
11
12
Prothrombin
Fibrinogen

Question 4

Clotting factors involved in extrinsic pathway

Answer 4

5
7
10
Prothrombin
Fibrinogen

Question 5

Used for the treatment of venous thromboses

Answer 5

Heparin

Warfarin

Question 6

Used for the treatment of arterial thromboses

Answer 6

Antiplatelets

Question 7

MOA of aspirin

Answer 7

Nonselective, irreversible COX inhibitor

Question 8

Prophylaxis of choice for the prevention of arterial thrombosis

Answer 8

Aspirin

Question 9

Toxic dose of aspirin

Answer 9

150mg/kg

Question 10

Lethal dose of aspirin

Answer 10

500mg/kg

Question 11

Triad of aspirin hypersensitivity

Answer 11

SAMTER TRIAD
Asthma
Aspirin sensitivity
Nasal polyps

Question 12

Expected acid-base abnormality in salicylate poisoning

Answer 12

Respiratory alkalosis with HAGMA

Question 13

Glycoprotein IIb/IIIa inhibitors

Answer 13

Abciximab
Eptifibatide
Tirofiban

Question 14

ADP inhibitors

Answer 14

Clopidogrel
Ticlopidine
Prasugel

Question 15

PDE III inhibitors

Answer 15

Dipyridamole

Cilostazole

Question 16

Anticoagulants

Answer 16

Heparin
Direct thrombin inhibitor
Warfarin

Question 17

Function of antithrombin III

Answer 17

Inactivates thrombin and factor Xa

Question 18

Used during PCI to prevent thrombosis

Answer 18

GP IIb/IIIa inhibitors (inhibits platelet aggregation

Question 19

Used for the prevention of restenosis after PCI

Answer 19

ADP inhibitors (reduces platelet aggregation)

Question 20

Causes TTP

Answer 20

Ticlopidine

Question 21

Used for the prevention of thromboembolic complications of cardiac valve replacement

Answer 21

PDE III inhibitors

Question 22

Used for the management of intermittent claudication

Answer 22

Cilostazol

Question 23

Cilostazol is contraindicated in patients with?

Answer 23

Heart failure

Question 24

2 major types of anticoagulants

Answer 24

Indirect thrombin inhibitors

Direct thrombin inhibitors

Question 25

Indirect thrombin inhibitors

Answer 25

Heparin Enoxaparin (LMWH) Lepirudin

Question 26

Direct thrombin inhibitors

Answer 26

Coumarin derivatives (warfarin)

Question 27

Anticoagulant of choice in pregnancy

Answer 27

Heparin

Question 28

MOA of heparin

Answer 28

Activates antithrombin III

Question 29

Antidote for heparin toxicity

Answer 29

Protamine sulfate

Question 30

LMWHs

Answer 30

``` Enoxaparin Dalteparin Tinzaparin Danaparoid Fondaparinux ```

Question 31

MOA of LMWH

Answer 31

Binds and potentiates effect of antithrombin III on factor Xa (more selective); less effect on thrombin

Question 32

Does not require aPTT monitoring

Answer 32

LMWH

Question 33

MOA of lepirudin

Answer 33

Binds to thrombin's active site and inhibits its enzymatic action

Question 34

Anticoagulant of choice in patients with HIT

Answer 34

Lepirudin Desirudin Bivalirudin Argatroban

Question 35

MOA of warfarin

Answer 35

Inhibits vitamin K epoxide reductase

Question 36

Used for chronic anticoagulation (DVT, afib, valve replacement) except in pregnancy

Answer 36

Warfarin

Question 37

Antidote for warfarin toxicity

Answer 37

``` Vitamin K (slow) FFP (fast) ```

Question 38

Effect of CP450 inducers on warfarin

Answer 38

Reduce anticoagulant effect

Question 39

Effect of CP450 inhibitors on warfarin

Answer 39

Increase anticoagulant effect

Question 40

Fibrinolytic drugs are used mainly for the treatment of?

Answer 40

Acute MI Ischemic stroke Massive pulmo embo

Question 41

tPA analogs (covert plasminogen to plasmin)

Answer 41

``` Alteplase Anistreplase Reteplase Streptokinase Tenecteplase Urokinase ```

Question 42

Antidote for tPA analog toxicity

Answer 42

Aminocaproic acid

Question 43

MOA of aminocaproic acid and tranexamic acid

Answer 43

Competitively inhibits plasminogen activation

Question 44

Aminocaproic acid and tranexamic acid are contraindicated in?

Answer 44

DIC | GU bleeding

Question 45

Used for hemophilia A, vWF disease, and Central DI

Answer 45

Demopressin

Question 46

Proaggregants

Answer 46

TXA2 5-HT ADP