Bacterial Protein Synthesis Inhibitors Flashcards Preview

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Flashcards in Bacterial Protein Synthesis Inhibitors Deck (45)
1

Moderate spectrum BPSI

Macrolides
Ketolide

2

Narrow spectrum BPSI

Lincosamides
Streptogramins
Linezolid

3

BUY AT 30, CELLS at 50

Aminoglycosides
Tetracycline
Chloramphenicol
Erythromycin
Lincosamides
Linezolid
Streptogramins

4

Causes aplastic anemia and gray baby syndrome

Chloramphenicol

5

Used for SIADH

Demeclocycline

6

Causes tooth enamel dysplasia/discoloration

Tetracycline

7

Do not take tetracycline with?

Milk (decreases absorption)

8

Indications of macrolides

CAP
Pertussis
Diphtheria
Chlamydial infections

9

All macrolides inhibit CYP450 except

Azithromycin

10

Macrolide with the highest Vd and slowest elimination

Azithromycin

11

Used for macrolide resistance

Telithromycin

12

Used for endocarditis prophylaxis (penicillin-allergy)

Clindamycin

13

Causes pseudomembranous colitis (C. difficile)

Clindamycin

14

Used for anaerobic infections above the diaphragm

Clindamycin

15

Used for anaerobic infections below the diaphragm

Metronidazole

16

Indication of quinupristin-dalfopristin
(Streptogramin) and Linezolid/Oxazolidinone

Infections caused by drug-resistant gram positive cocci (MRSA, VRSA, VRE)

17

Causes arthralgia-myalgia syndrome

Streptogramins

18

Causes serotonin syndrome

Linezolid

19

Mode of antibacterial action of aminoglycosides

Concentration-dependent killing action

20

Mode of antibacterial action of penicillins and cephalosporins

Time-dependent killing action

21

What is the basis for once-daily dosing of aminoglycosides?

Post-antibiotic effect

22

Least resistance but has the narrowest therapeutic window among aminoglycosides

Amikacin

23

Aminoglycosides

GNATS canNOT kill anaerobes
Gentamycin
Neomycin
Amikacin
Tobramycin
Streptomycin
Nephrotoxicity
Ototoxicity
Teratogen

24

Most vestibulotoxic and nephrotoxic aminoglycosides

Gentamicin
Tobramycin

25

2nd line drug for MDRTB

Amikacin

26

Teratogen (causes congenital deafness); administered IM

Streptomycin

27

Used as bowel prep for elective surgery and for hepatic encephalopathy

Neomycin (topical and oral)

28

Used for the treatment of visceral leishmaniasis

Paromomycin

29

Most ototoxic aminoglycosides

Kanamycin

30

How do you reverse the neuromuscular blockade caused by neomycin?

Give calcium gluconate and neostigmime

31

Cumulative ototoxicity occurs when aminoglycosides are given with?

Loop diuretics

32

Broad spectrum BPSI

Chloramphenicol
Tetracyclines

33

Tetracycline which has the the broadest spectrum (less resistance)

Tigecycline

34

Toxicities of tetracycline

Deposition in developing bones and teeth, photosensitivity, superinfection

35

The only bacterial protein synthesis inhibitor which is bactericidal

Streptogramins

36

Causes QT prolongation

Macrolides

37

MOA of doxycyline

Interference with binding of aminoacyl-tRNA to bacterial ribosomes

38

Clarithromycin vs Erythromycin

Clarithromycin is more active than erythromycin against M. avium complex, T. gondii, and H. pylori

39

Primary mechanism of resistance of gram-positive organisms to erythromycin

Methylation of binding sites on the 50s ribosomal subunit

40

DOC of Chlamydial infection (non compliant patient)

Single oral dose of azithromycin

41

DOC for prophylaxis in high-risk penicillin-allergic patients undergoing genitourinary and lower GI surgical procedures

IV vancomycin

42

DOC of CAP

Monotherapy:
Macrolides
Doxycycline
Respiratory quinolone

43

Macrolides should not be taken with?

Methylxanthines (caffeine)

44

Causes dose-related anemia

Chloramphenicol
Oxazolidinone (Linezolid)

45

Causes Fanconi's syndrome

Tetracycline