Flashcards in Drugs For Hyperlipidemias Deck (29)
Hepatotoxicity is increased when ezetimibe is used with?
Avoided in patients with hypertriglyceridemia because it raises TG and VLDL levels
HMG-Coa Synthase is used for?
HMG-Coa reductase is used for?
Bile acid-binding resins (BARs)
Mnemonic: ChoCoCo BAR
Used for the management of pruritus in cholestasis and digitalis toxicity
Bile acid binding-resins (BARs)
SE of bile acid-binding resins
Malabsorption of fat soluble vitamins
Increases TGs and VLDL in patients with high TGs
BARs should be avoided in patients with?
MOA of ezetimibe
Selective inhibitor of the NPC1L1 transporter, decreasing intestinal absorption of cholesterol and other phytosterols
Ezetimibe have synergistic LDL-lowering effects with?
Cholesterol analog; decreases intestinal absorption of cholesterol and other phytosterols
Most effective agent for increasing HDL levels; decreases VLDL and LDL
Niacin (nicotinic acid)
Niacin is contraindicated in patients with?
Flushing caused by niacin is reduced by giving?
Drugs that cause flushing
MOA of fibrates
Activates PPAR-alpha; increases synthesis of lipoprotein lipase and apolipoproteins (apoA-I and apoA-II); increases HDL
DOC for hypertriglyceridemia
Mnemonic: FIB in the middle
Used in fat redistribution syndrome
Causes cholesterol gallstones
Used for familial hypercholesterolemia
Niacin + statin or
Statin + ezetimibe
Used for familial combined hypercholesterolemia
Niacin + resin or
Statin + fibrate
Increased risk of cholelithiasis
Fibrate + resin
Impaired statin absorption
Statin + resin
There is increased risk of myopathy and rhabdomyolysis when statins are used with?
MOA of niacin
Niacin inhibits VLDL secretion, in turn decreasing production of LDL. Increased clearance of VLDL via the LPL pathway contributes to reduction of triglycerides
Contraindicated in pregnancy