Drugs For Hyperlipidemias Flashcards Preview

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Flashcards in Drugs For Hyperlipidemias Deck (29)
1

Hepatotoxicity is increased when ezetimibe is used with?

Statins

2

Avoided in patients with hypertriglyceridemia because it raises TG and VLDL levels

Alcohol

3

HMG-Coa Synthase is used for?

Ketogenesis

4

HMG-Coa reductase is used for?

Cholesterol synthesis

5

Bile acid-binding resins (BARs)

Cholestyramine
Colesevelam
Colestipol

Mnemonic: ChoCoCo BAR

6

Used for the management of pruritus in cholestasis and digitalis toxicity

Bile acid binding-resins (BARs)

7

SE of bile acid-binding resins

Constipation
Bloating
Gritty taste
Steatorrhea
Gallstones (rare)
Malabsorption of fat soluble vitamins

8

Increases TGs and VLDL in patients with high TGs

BARs

9

BARs should be avoided in patients with?

Diverticulitis

10

MOA of ezetimibe

Selective inhibitor of the NPC1L1 transporter, decreasing intestinal absorption of cholesterol and other phytosterols

11

Ezetimibe have synergistic LDL-lowering effects with?

Statins

12

Cholesterol analog; decreases intestinal absorption of cholesterol and other phytosterols

Sitosterol

13

Most effective agent for increasing HDL levels; decreases VLDL and LDL

Niacin (nicotinic acid)

14

Niacin is contraindicated in patients with?

DM
Gout
PUD

15

Flushing caused by niacin is reduced by giving?

Aspirin

16

Drugs that cause flushing

VANC
Vancomycin
Adenosine
Niacin
CCBs

17

MOA of fibrates

Activates PPAR-alpha; increases synthesis of lipoprotein lipase and apolipoproteins (apoA-I and apoA-II); increases HDL

Mnemonic: FALL-TRI
Fibrates
Alpha (PPAR-alpha)
Lipoprotein
Lipase increases
TRIglycerides lowers

18

DOC for hypertriglyceridemia

Fibrates

19

Fibrates

Gemfibrozil
Fenofibrate
Bezafibrate

Mnemonic: FIB in the middle

20

Used in fat redistribution syndrome

Fibrates

21

Causes cholesterol gallstones

Fibrates

22

Used for familial hypercholesterolemia

Niacin + statin or
Statin + ezetimibe

23

Used for familial combined hypercholesterolemia

Niacin + resin or
Statin + fibrate

24

Increased risk of cholelithiasis

Fibrate + resin

25

Impaired statin absorption

Statin + resin

26

There is increased risk of myopathy and rhabdomyolysis when statins are used with?

Fibrates

27

MOA of niacin

Niacin inhibits VLDL secretion, in turn decreasing production of LDL. Increased clearance of VLDL via the LPL pathway contributes to reduction of triglycerides

28

Contraindicated in pregnancy

Statins

29

Causes hyperuricemia and glucose intolerance

Niacin