Hypothalamic and Pituitary Hormones Flashcards Preview

Pharmacology > Hypothalamic and Pituitary Hormones > Flashcards

Flashcards in Hypothalamic and Pituitary Hormones Deck (28)
1

Anterior pituitary hormones which act through G protein-coupled receptors

TSH
ACTH
FSH
LH

2

Anterior pituitary hormones which act through JAK/STAT receptors

GH
Prolactin

3

Effect of endogenous GnRH on LH and FSH

Stimulates release

4

Effect of exogenous GnRH on LH and FSH

Inhibits release

5

MOA of Somatropin (Growth hormone)

Increases release of IGF-1 in the liver and cartilage

6

MOA of octreotide (somatostatin analog)

Suppresses secretion of growth hormone, IGF-1, and serotonin and GI peptides

7

Used in patients with GH deficiency, genetic diseases associated with short stature (Turner, Noonan, Prader-Willi), failure to thrive, and AIDS wasting

Somatropin

8

Used in patients with acromegaly, pituitary adenoma (GH-secreting), carcinoid, gastrinoma, glucagonoma, and variceal bleeding

Octreotide

9

Inhibits the release of GH, glucagon, insulin, and gastrin

Somatostatin

10

GH receptor antagonist that is approved for treatment of acromegaly

Pegvisomant

11

Directs follicle development in women

FSH

12

Collaborates in regulating ovarian steroidogenesis

FSH and LH

13

Regulates spermatogenesis

FSH

14

Stimulates androgen production in men

LH

15

Final stage of oocyte maturation is induced with an injection of?

LH or hCG

16

An FSH analog (FSH receptor agonist) used for controlled ovarian stimulation and for men who are infertile due to hypogonadism

Follitropin alfa

17

An LH analog which is used for hypogonadotropic hypogonadism

Choriogonadotropin alfa

18

A GnRH analog (LH receptor agonist) used for endometriosis, myoma uteri, precocious puberty, and prostate ca

Leuprolide

19

Drug that prevents acute flare ups of prostate ca caused by Leuprolide

Flutamide

20

A GnRH antagonist which prevents premature LH surge

Ganirelix

21

Does not cause flare ups of prostate ca

Ganirelix

22

A partial agonist at D2 receptors in the brain which is used for the treatment of hyperprolactinemia

Bromocriptine

23

A vasopressin V2 receptor agonist which is used for the treatment of central diabetes insipidus, hemophilia A, and von Willebrand's disease

Desmopressin

24

Syndrome of polyuria, polydipsia, and hypernatremia

Diabetes insipidus

25

Antagonist of V1a and V2 receptors which is used for SIADH and hyponatremia

Conivaptan

26

A vasopressin receptor antagonist which is more selective for vasopressin V2 receptors

Tolvaptan

27

An oxytocin receptor antagonist which is used for tocolysis of preterm labor

Atosiban

28

Hormones derived from basophilic cells

B FLAT
FSH
LH
ACTH
TSH