Hypothalamic and Pituitary Hormones

Question 1

Anterior pituitary hormones which act through G protein-coupled receptors

Answer 1

TSH
ACTH
FSH
LH

Question 2

Anterior pituitary hormones which act through JAK/STAT receptors

Answer 2

GH

Prolactin

Question 3

Effect of endogenous GnRH on LH and FSH

Answer 3

Stimulates release

Question 4

Effect of exogenous GnRH on LH and FSH

Answer 4

Inhibits release

Question 5

MOA of Somatropin (Growth hormone)

Answer 5

Increases release of IGF-1 in the liver and cartilage

Question 6

MOA of octreotide (somatostatin analog)

Answer 6

Suppresses secretion of growth hormone, IGF-1, and serotonin and GI peptides

Question 7

Used in patients with GH deficiency, genetic diseases associated with short stature (Turner, Noonan, Prader-Willi), failure to thrive, and AIDS wasting

Answer 7

Somatropin

Question 8

Used in patients with acromegaly, pituitary adenoma (GH-secreting), carcinoid, gastrinoma, glucagonoma, and variceal bleeding

Answer 8

Octreotide

Question 9

Inhibits the release of GH, glucagon, insulin, and gastrin

Answer 9

Somatostatin

Question 10

GH receptor antagonist that is approved for treatment of acromegaly

Answer 10

Pegvisomant

Question 11

Directs follicle development in women

Answer 11

FSH

Question 12

Collaborates in regulating ovarian steroidogenesis

Answer 12

FSH and LH

Question 13

Regulates spermatogenesis

Answer 13

FSH

Question 14

Stimulates androgen production in men

Answer 14

LH

Question 15

Final stage of oocyte maturation is induced with an injection of?

Answer 15

LH or hCG

Question 16

An FSH analog (FSH receptor agonist) used for controlled ovarian stimulation and for men who are infertile due to hypogonadism

Answer 16

Follitropin alfa

Question 17

An LH analog which is used for hypogonadotropic hypogonadism

Answer 17

Choriogonadotropin alfa

Question 18

A GnRH analog (LH receptor agonist) used for endometriosis, myoma uteri, precocious puberty, and prostate ca

Answer 18

Leuprolide

Question 19

Drug that prevents acute flare ups of prostate ca caused by Leuprolide

Answer 19

Flutamide

Question 20

A GnRH antagonist which prevents premature LH surge

Answer 20

Ganirelix

Question 21

Does not cause flare ups of prostate ca

Answer 21

Ganirelix

Question 22

A partial agonist at D2 receptors in the brain which is used for the treatment of hyperprolactinemia

Answer 22

Bromocriptine

Question 23

A vasopressin V2 receptor agonist which is used for the treatment of central diabetes insipidus, hemophilia A, and von Willebrand’s disease

Answer 23

Desmopressin

Question 24

Syndrome of polyuria, polydipsia, and hypernatremia

Answer 24

Diabetes insipidus

Question 25

Antagonist of V1a and V2 receptors which is used for SIADH and hyponatremia

Answer 25

Conivaptan

Question 26

A vasopressin receptor antagonist which is more selective for vasopressin V2 receptors

Answer 26

Tolvaptan

Question 27

An oxytocin receptor antagonist which is used for tocolysis of preterm labor

Answer 27

Atosiban

Question 28

Hormones derived from basophilic cells

Answer 28

``` B FLAT FSH LH ACTH TSH ```