Antiviral Chemotherapy and Prophylaxis Flashcards Preview

Pharmacology > Antiviral Chemotherapy and Prophylaxis > Flashcards

Flashcards in Antiviral Chemotherapy and Prophylaxis Deck (32)
1

MOA of Foscarnet

Inhibits viral RNA polymerase, DNA polymerase, and HIV reverse transcriptase

2

Antiviral spectrum of acyclovir

HSV-1
HSV-2
VZV

3

Antiviral spectrum of ganciclovir

CMV
HSV-1
HSV-2
VZV

4

Inhibits fusion between the HSV envelope and plasma membranes

Docosanol

5

Used in CMV retinitis, acyclovir-resistance, ganciclovir-resistance, genital warts, molluscum contagiosum, and mucocutaneous HSV infections

Cidofovir

6

Used in HSV infection in patients with AIDS

Foscarnet

7

NNRTIs

Never ever deliver nucleosides
Nevirapine
Efavirenz
Delavirdine

8

Used for the prevention of maternal-fetal HIV transmission

NRTIs:
Zidovudine
Lamivudine
Tenofovir
Didanosine

9

Inhibits HIV reverse transcriptase after phosphorylation by cellular enzymes

NRTIs

10

Inhibits HIV reverse transcriptase without phosphorylation

NNRTIs

11

NRTI which causes bone marrow suppression

Zidovudine

12

NRTI which causes pancreatitis

Didanosine

13

NRTI which causes peripheral neuropathy

Stavudine
Zalcitabine

14

NNRTIs which causes increased AST/ALT

Delavirdine
Nevirapine

15

NNRTIs which is teratogenic

Efavirenz

16

NNRTIs which causes increased cholesterol and TG

Etravirine

17

Protease inhibitor

-navir
Indinavir

18

Causes hyperbilirubinemia and nephrolithiasis

Indinavir

19

Causes GI distress and diarrhea

Saquinavir

20

Fusion inhibitor; binds to gp41 subunit preventing fusion of viral and cellular membranes

Enfuvirtide

21

CCR5 receptor antagonist; blocks viral attachment

Maraviroc

22

Used in influenza A only

Amantadine (prevents uncoating)

23

Causes cerebellar dysfunction and livedo reticularis

Amantadine

24

MOA of oseltamivir and zanamivir

Inhibits neuraminidase; decreases release of progeny virus

25

Causes bronchospasm in asthmatics

Zanamivir

26

DOC for influenza (including H1N1)

Oseltamivir

27

Used in HBV infection, HCV infection, and kaposi sarcoma

Interferon alpha

28

MOA of Lamivudine

Inhibits HBV DNA polymerase

29

Used in HBV and HIV infection

Lamivudine

30

MOA of ribavirin

Inhibits guanosine triphosphate formation

31

Used in HCV and RSV infection

Ribavirin

32

MOA of acyclovir

Activated by viral thymidine kinase (TK) to forms that inhibit viral DNA polymerase