Antiviral Chemotherapy and Prophylaxis

Question 1

MOA of Foscarnet

Answer 1

Inhibits viral RNA polymerase, DNA polymerase, and HIV reverse transcriptase

Question 2

Antiviral spectrum of acyclovir

Answer 2

HSV-1
HSV-2
VZV

Question 3

Antiviral spectrum of ganciclovir

Answer 3

CMV
HSV-1
HSV-2
VZV

Question 4

Inhibits fusion between the HSV envelope and plasma membranes

Answer 4

Docosanol

Question 5

Used in CMV retinitis, acyclovir-resistance, ganciclovir-resistance, genital warts, molluscum contagiosum, and mucocutaneous HSV infections

Answer 5

Cidofovir

Question 6

Used in HSV infection in patients with AIDS

Answer 6

Foscarnet

Question 7

NNRTIs

Answer 7

Never ever deliver nucleosides
Nevirapine
Efavirenz
Delavirdine

Question 8

Used for the prevention of maternal-fetal HIV transmission

Answer 8

NRTIs:
Zidovudine
Lamivudine
Tenofovir
Didanosine

Question 9

Inhibits HIV reverse transcriptase after phosphorylation by cellular enzymes

Answer 9

NRTIs

Question 10

Inhibits HIV reverse transcriptase without phosphorylation

Answer 10

NNRTIs

Question 11

NRTI which causes bone marrow suppression

Answer 11

Zidovudine

Question 12

NRTI which causes pancreatitis

Answer 12

Didanosine

Question 13

NRTI which causes peripheral neuropathy

Answer 13

Stavudine

Zalcitabine

Question 14

NNRTIs which causes increased AST/ALT

Answer 14

Delavirdine

Nevirapine

Question 15

NNRTIs which is teratogenic

Answer 15

Efavirenz

Question 16

NNRTIs which causes increased cholesterol and TG

Answer 16

Etravirine

Question 17

Protease inhibitor

Answer 17

-navir

Indinavir

Question 18

Causes hyperbilirubinemia and nephrolithiasis

Answer 18

Indinavir

Question 19

Causes GI distress and diarrhea

Answer 19

Saquinavir

Question 20

Fusion inhibitor; binds to gp41 subunit preventing fusion of viral and cellular membranes

Answer 20

Enfuvirtide

Question 21

CCR5 receptor antagonist; blocks viral attachment

Answer 21

Maraviroc

Question 22

Used in influenza A only

Answer 22

Amantadine (prevents uncoating)

Question 23

Causes cerebellar dysfunction and livedo reticularis

Answer 23

Amantadine

Question 24

MOA of oseltamivir and zanamivir

Answer 24

Inhibits neuraminidase; decreases release of progeny virus

Question 25

Causes bronchospasm in asthmatics

Answer 25

Zanamivir

Question 26

DOC for influenza (including H1N1)

Answer 26

Oseltamivir

Question 27

Used in HBV infection, HCV infection, and kaposi sarcoma

Answer 27

Interferon alpha

Question 28

MOA of Lamivudine

Answer 28

Inhibits HBV DNA polymerase

Question 29

Used in HBV and HIV infection

Answer 29

Lamivudine

Question 30

MOA of ribavirin

Answer 30

Inhibits guanosine triphosphate formation

Question 31

Used in HCV and RSV infection

Answer 31

Ribavirin

Question 32

MOA of acyclovir

Answer 32

Activated by viral thymidine kinase (TK) to forms that inhibit viral DNA polymerase