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Flashcards in Thyroid and Antithyroid Drugs Deck (24)
1

Methimazole and PTU are collectively termed as?

Thioamides

2

How many weeks does it take for thioamides to take full effect?

3-4 weeks

3

Enzyme that converts iodide ion to iodine

Thyroid peroxidase

4

Treatment for myxedema coma

IV loading dose of levothyroxine (300-400mcg) followed by 50-100mcg daily

5

MOA of PTU

Mnemonic: TOP

Inhibits TPO,
Blocks iodine organification,
Inhibits peripheral conversion of T4 into T3

6

DOC for pregnant hyperthyroid patients

PTU

7

MOA of methimazole

Mnemonic: MOT

Blocks organification,
Inhibits TPO

8

Antithyroid drugs which cause agranulocytosis and hepatitis

PTU
Methimazole

9

Antithyroid drug which causes cholestatic jaundice

Methimazole

10

Prenatal exposure of methimazole causes what congenital disease?

Aplasia cutis congenita (smaller version of SJS)

11

Treatment for agranulocytosis

D/c drug
Administer recombinant G-CSF (Filgastrin)
Give broad-spectrum antibiotics

12

Used in the management of thyroid storm and to prepare patients for surgical resection of a hyperactive thyroid; reduces the size and vascularity of the thyroid gland; administered 10-14d before surgery

Iodide salts (Potassium iodide/Lugol's solution)

13

MOA of iodide salts

Inhibits iodine organification and hormone release

14

Prevents radiation-induced thyroid damage

Iodide salts

15

Prenatal exposure of this drug causes fetal goiter

Iodide salts

16

Ingestion of iodine causes hypothyroidism

Wolf-Chaikoff effect

17

Ingestion of iodine causes hyperthyroidism

Jod-Basedow phenomenon

18

MOA of propranolol

A beta blocker which inhibits peripheral conversion of T4 into T3

19

Used to treat thyrotoxicosis-related arrhythmias

Esmolol

20

Antithyroid drugs which inhibit the peripheral conversion of T4 to T3

PTU
Propranolol
Hydrocortisone

21

Drugs that cause drug-induced hyperthyroidism

Clofibrate
Amiodarone
Methadone

22

Treatment of thyroid storm

Propranolol (rapid onset)

23

T3 is how many times more potent than T4?

10x

24

Antiarrhythmic drug that inhibits peripheral conversion of T4 to T3

Amiodarone