Adrenergic Pharmacology Flashcards Preview

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Flashcards in Adrenergic Pharmacology Deck (82)
1

Vasoconstricts renal blood vessels

Norepinephrine

2

Inhibits hydroxylation of tyrosine to DOPA

Metyrosine

3

Inhibits vesicular transport of NE and dopamine

Reserpine

4

Inhibits release of NE

Guanethidine

5

Promotes release of NE

Amphetamines
Tyramine

6

Diffusion and reuptake of NE is inhibited by?

Cocaine
TCAs

7

Increases stores of NE and dopamine

MAOIs

8

Non-selective, direct-acting sympathomimetic

Epinephrine
Norepinephrine
Dopamine

9

Beta-nonselective sympathomimetic

Isoproterenol

10

Alpha 1-selective sympathomimetics

Phenylephrine
Pseudoephedrine

11

Alpha 2 selective sympathomimetics

Clonidine
Apraclonidine
Methyldopa
Brimonidine

12

Beta 1-selective sympathomimetic

Dobutamine

13

Beta 2-selective sympathomimetic

Albuterol/salbutamol
Ritodrine
Terbutaline

14

Alpha-nonselective adrenergic antagonist

Phenoxybenzamine
Phentolamine

15

Alpha 1-selective antagonist

Prazosin
Doxazosin
Terazosin
Tamsulosin
Silodosin

16

Beta-nonselective antagonist

Propranolol
Pindolol
Timolol
Labetalol
Carvedilol
Nadolol

17

Beta 1-selective antagonist

Atenolol
Betaxolol
Esmolol
Acebutolol
Metoprolol

18

Used in cardiac arrest, anaphylaxis, asthma, COPD, Hemostasis

Epinephrine

19

Used in neurogenic shock and cardiogenic shock (last resort)

Norepinephrine

20

First line drug for shock; used in heart failure

Dopamine

21

Low dose dopamine (1-5mcg/kg/min) activates what receptors?

D1 receptors

22

Medium dose dopamine (5-15mcg/kg/min) stimulates what receptors?

B1 receptors

23

High dose (>15mcg/kg/min) stimulates what receptors?

Alpha receptors

24

Beta-nonselective sympathomimetic used for asthma; causes tachycardia

Isoproterenol

25

Decongestant; mydriatic; causes rebound nasal congestion

Phenylephrine
Pseudoephedrine

26

Causes mydriasis without cycloplegia

Phenylephrine
Pseudoephedrine

27

Used for hypertension, cancer pain, and opioid withdrawal

Clonidine

28

Used to treat rebound hypertension caused by clonidine

Phentolamine

29

Used for pre-eclampsia

Methyldopa
(Alpha 2-selective)

30

SE of methyldopa

Sedation
Hemolytic anemia (positive Coomb's test)

31

Alpha 2-selective sympathomimetic used for glaucoma

Apraclonidine

32

Used for acute heart failure; DOC for cardiogenic shock

Dobutamine
(Beta 1-selective sympathomimetic)

33

Used in cardiac testing for amputated patients

Dobutamine

34

DOC for acute attacks of asthma

Albuterol/salbutamol

35

Used for tocolysis of preterm labor

Terbutaline
Ritodrine

36

Beta 2-selective sympathomimetics may precipitate arrhythmias in patient with concurrent?

COPD and heart disease

37

Sympathomimetic of choice for acute heart failure and septic shock

B1 and D1 agonist

38

Sympathomimetic of choice for hemostasis, decongestion, and spinal shock

Alpha 1 agonist

39

Sympathomimetic of choice for bronchospasm and premature labor

B2 agonist

40

Sympathomimetic of choice for hypertension and glaucoma

Alpha 2 agonist

41

Irreversible, nonselective, alpha blocker

Phenoxybenzamine

42

Reversible, nonselective, alpha blocker

Phentolamine

43

Alpha 1-selective blocker

Prazosin
Terazosin
Tamsulosin
Silodosin

44

Alpha 2-selective blocker

Yohimbine

45

Nonselective beta blocker

Propranolol
Pindolol
Timolol
Labetalol
Carvedilol
Nadolol

46

Beta 1-selective blocker

Atenolol
Betaxolol
Esmolol
Acebutolol
Metoprolol

47

Beta 2-selective blocker

Butoxamine

48

Used for pheochromocytoma (pre-surgical)

Phenoxybenzamine
Phentolamine

49

Most selective for prostatic smooth muscle

Tamsulosin

50

Used for BPH

Alpha 1-selective blocker

51

Pharmacologic advantage of alpha 1-selectivity

Reflex tachycardia is less common and less severe

52

Beta blockers which may be used for pheochromocytoma

Carvedilol
Labetalol

53

Causes erectile dysfunction

Beta blockers

54

Beta blocker with the longest half-life

Nadolol

55

Beta blockers with absent local anesthetic activity; useful in glaucoma (decreases aqueous secretion from the ciliary epithelium)

Timolol
Betaxolol

56

B1 blocker used for SVT

Esmolol

57

Beta blocker with the shortest half-life

Esmolol

58

Vasodilates renal blood vessels

Dopamine

59

Alpha 1 agonists

Midodrine
Phenylephrine

60

MOA of alpha-1 agonists

Activates phospholipase C, resulting in increased intracellular calcium and vasoconstriction (increases BP)

61

Indication for alpha-1 agonists

Orthostatic hypotension

62

Toxicity of alpha-1 agonists

Supine hypertension; piloerection (goosebumps); urinary retention

63

Alpha-1 agonist used as a decongestant

Phenylephrine

64

Alpha-2 agonists

Clonidine
Methyldopa
Dexmedetomidine
Tizanidine
Apraclonidine
Brimonidine

65

Mechanism of action of alpha-2 agonists

Inhibits adenylyl cyclase and interacts with other intracellular pathways; vasoconstriction is masked by central sympatholytic effect, which lowers BP

66

Indication of alpha-2 agonists

Hypertension

67

Toxicity of alpha-2 agonists

Dry mouth and sedation

68

Alpha-2 agonists used in glaucoma to reduce intraocular pressure (decreases aqueous secretion)

Apraclonidine
Brimonidine

69

B1 agonist

Dobutamine

70

MOA of B1 agonist

Activates adenylyl cyclase, increasing myocardial contractility; positive inotrope

71

Indication of B1 agonist

Cardiogenic shock; acute heart failure

72

B2 agonist

Albuterol

73

MOA of B2 agonist

Activates adenylyl cyclase; bronchodilation

74

Indication of B2 agonist

Asthma

75

Toxicities of B2 agonist

Tremor
Tachycardia

76

D1 agonist

Fenoldopam

77

MOA of D1 agonist

Activates adenylyl cyclase; vascular smooth muscle relaxation

78

Indication of D1 agonist

Hypertension

79

D2 agonist

Bromocriptine

80

MOA of D2 agonist

Inhibits adenylyl cyclase and interacts with other cellular pathways; restores dopamine actions in the CNS

81

Indications of D2 agonist

Parkinson's disease; prolactinemia

82

Toxicity of D2 agonist

Orthostatic hypotension