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Pharmacology > Adrenergic Pharmacology > Flashcards

Adrenergic Pharmacology Flashcards

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1
Q

Vasoconstricts renal blood vessels

A

Norepinephrine

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2
Q

Inhibits hydroxylation of tyrosine to DOPA

A

Metyrosine

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3
Q

Inhibits vesicular transport of NE and dopamine

A

Reserpine

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4
Q

Inhibits release of NE

A

Guanethidine

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5
Q

Promotes release of NE

A

Amphetamines

Tyramine

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6
Q

Diffusion and reuptake of NE is inhibited by?

A

Cocaine

TCAs

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7
Q

Increases stores of NE and dopamine

A

MAOIs

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8
Q

Non-selective, direct-acting sympathomimetic

A

Epinephrine
Norepinephrine
Dopamine

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9
Q

Beta-nonselective sympathomimetic

A

Isoproterenol

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10
Q

Alpha 1-selective sympathomimetics

A

Phenylephrine

Pseudoephedrine

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11
Q

Alpha 2 selective sympathomimetics

A

Clonidine
Apraclonidine
Methyldopa
Brimonidine

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12
Q

Beta 1-selective sympathomimetic

A

Dobutamine

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13
Q

Beta 2-selective sympathomimetic

A

Albuterol/salbutamol
Ritodrine
Terbutaline

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14
Q

Alpha-nonselective adrenergic antagonist

A

Phenoxybenzamine

Phentolamine

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15
Q

Alpha 1-selective antagonist

A 
Prazosin
Doxazosin
Terazosin
Tamsulosin
Silodosin
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16
Q

Beta-nonselective antagonist

A 
Propranolol
Pindolol
Timolol
Labetalol
Carvedilol
Nadolol
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17
Q

Beta 1-selective antagonist

A 
Atenolol
Betaxolol
Esmolol
Acebutolol
Metoprolol
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18
Q

Used in cardiac arrest, anaphylaxis, asthma, COPD, Hemostasis

A

Epinephrine

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19
Q

Used in neurogenic shock and cardiogenic shock (last resort)

A

Norepinephrine

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20
Q

First line drug for shock; used in heart failure

A

Dopamine

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21
Q

Low dose dopamine (1-5mcg/kg/min) activates what receptors?

A

D1 receptors

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22
Q

Medium dose dopamine (5-15mcg/kg/min) stimulates what receptors?

A

B1 receptors

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23
Q

High dose (>15mcg/kg/min) stimulates what receptors?

A

Alpha receptors

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24
Q

Beta-nonselective sympathomimetic used for asthma; causes tachycardia

A

Isoproterenol

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25
Decongestant; mydriatic; causes rebound nasal congestion
Phenylephrine | Pseudoephedrine
26
Causes mydriasis without cycloplegia
Phenylephrine | Pseudoephedrine
27
Used for hypertension, cancer pain, and opioid withdrawal
Clonidine
28
Used to treat rebound hypertension caused by clonidine
Phentolamine
29
Used for pre-eclampsia
Methyldopa | Alpha 2-selective
30
SE of methyldopa
``` Sedation Hemolytic anemia (positive Coomb's test) ```
31
Alpha 2-selective sympathomimetic used for glaucoma
Apraclonidine
32
Used for acute heart failure; DOC for cardiogenic shock
Dobutamine | Beta 1-selective sympathomimetic
33
Used in cardiac testing for amputated patients
Dobutamine
34
DOC for acute attacks of asthma
Albuterol/salbutamol
35
Used for tocolysis of preterm labor
Terbutaline | Ritodrine
36
Beta 2-selective sympathomimetics may precipitate arrhythmias in patient with concurrent?
COPD and heart disease
37
Sympathomimetic of choice for acute heart failure and septic shock
B1 and D1 agonist
38
Sympathomimetic of choice for hemostasis, decongestion, and spinal shock
Alpha 1 agonist
39
Sympathomimetic of choice for bronchospasm and premature labor
B2 agonist
40
Sympathomimetic of choice for hypertension and glaucoma
Alpha 2 agonist
41
Irreversible, nonselective, alpha blocker
Phenoxybenzamine
42
Reversible, nonselective, alpha blocker
Phentolamine
43
Alpha 1-selective blocker
Prazosin Terazosin Tamsulosin Silodosin
44
Alpha 2-selective blocker
Yohimbine
45
Nonselective beta blocker
``` Propranolol Pindolol Timolol Labetalol Carvedilol Nadolol ```
46
Beta 1-selective blocker
``` Atenolol Betaxolol Esmolol Acebutolol Metoprolol ```
47
Beta 2-selective blocker
Butoxamine
48
Used for pheochromocytoma (pre-surgical)
Phenoxybenzamine | Phentolamine
49
Most selective for prostatic smooth muscle
Tamsulosin
50
Used for BPH
Alpha 1-selective blocker
51
Pharmacologic advantage of alpha 1-selectivity
Reflex tachycardia is less common and less severe
52
Beta blockers which may be used for pheochromocytoma
Carvedilol | Labetalol
53
Causes erectile dysfunction
Beta blockers
54
Beta blocker with the longest half-life
Nadolol
55
Beta blockers with absent local anesthetic activity; useful in glaucoma (decreases aqueous secretion from the ciliary epithelium)
Timolol | Betaxolol
56
B1 blocker used for SVT
Esmolol
57
Beta blocker with the shortest half-life
Esmolol
58
Vasodilates renal blood vessels
Dopamine
59
Alpha 1 agonists
Midodrine | Phenylephrine
60
MOA of alpha-1 agonists
Activates phospholipase C, resulting in increased intracellular calcium and vasoconstriction (increases BP)
61
Indication for alpha-1 agonists
Orthostatic hypotension
62
Toxicity of alpha-1 agonists
Supine hypertension; piloerection (goosebumps); urinary retention
63
Alpha-1 agonist used as a decongestant
Phenylephrine
64
Alpha-2 agonists
``` Clonidine Methyldopa Dexmedetomidine Tizanidine Apraclonidine Brimonidine ```
65
Mechanism of action of alpha-2 agonists
Inhibits adenylyl cyclase and interacts with other intracellular pathways; vasoconstriction is masked by central sympatholytic effect, which lowers BP
66
Indication of alpha-2 agonists
Hypertension
67
Toxicity of alpha-2 agonists
Dry mouth and sedation
68
Alpha-2 agonists used in glaucoma to reduce intraocular pressure (decreases aqueous secretion)
Apraclonidine | Brimonidine
69
B1 agonist
Dobutamine
70
MOA of B1 agonist
Activates adenylyl cyclase, increasing myocardial contractility; positive inotrope
71
Indication of B1 agonist
Cardiogenic shock; acute heart failure
72
B2 agonist
Albuterol
73
MOA of B2 agonist
Activates adenylyl cyclase; bronchodilation
74
Indication of B2 agonist
Asthma
75
Toxicities of B2 agonist
Tremor | Tachycardia
76
D1 agonist
Fenoldopam
77
MOA of D1 agonist
Activates adenylyl cyclase; vascular smooth muscle relaxation
78
Indication of D1 agonist
Hypertension
79
D2 agonist
Bromocriptine
80
MOA of D2 agonist
Inhibits adenylyl cyclase and interacts with other cellular pathways; restores dopamine actions in the CNS
81
Indications of D2 agonist
Parkinson's disease; prolactinemia
82
Toxicity of D2 agonist
Orthostatic hypotension

Pharmacology (31 decks)

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