Antifungal Agents Flashcards Preview

Pharmacology > Antifungal Agents > Flashcards

Flashcards in Antifungal Agents Deck (23)
1

MOA of ketoconazole, fluconazole, itraconazole, clotrimazole, and miconazole

Inhibits fungal P450-dependent enzymes blocking ergosterol synthesis (Fungistatic)

2

MOA of Echinocandins (caspofungin)

Inhibits B-glucan synthase decreasing fungal cell wall synthesis

3

MOA of griseofulvin

Interferes with microtubule formation

4

MOA of terbinafine

Inhibits squalene oxidase thereby interfering with ergosterol synthesis

Mnemonic: SQUATER
SQUAlene oxidase
TERbinafine

5

MOA of amphotericin B and nystatin

Binds to ergosterol in fungal cell membranes, forming artificial pores (fungicidal)

6

Nephrotoxic: causes RTA

Amphotericin B

7

Used in chronic mucocutaneous candidiasis and dermatophytosis

Ketoconazole

8

Used in candidiasis (esophageal, oropharyngeal, vuvovaginitis)

Fluconazole

9

Fluconazole is used for the treatment and prophylaxis of?

Cryptococcal meningitis

10

Used in sporotrichosis

Itraconazole

11

Used as salvage therapy for invasive aspergillosis as well as for disseminated and mucocutaneous candidiasis

Caspofungin

12

Causes histamine release (flushing)

Caspofungin

13

Potent CYP450 inducer

Griseofulvin

griseofulvINDUCER

14

Potent CYP450 inhibitor

Ketoconazole

15

Used in onychomycosis

Terbinafine

16

Used for candidiasis (oropharyngeal, esophageal, and vaginal)

Nystatin

17

Used for seborrheic dermatitis and pityriasis versicolor

Clotrimazole

SCALPtrimazole

18

MOA of flucytosine

Inhibits DNA and RNA polymerases

19

Azoles with activity against Aspergillus

Itraconazole
Voriconazole

20

The only azole which readily penetrates the BBB

Fluconazole

21

Azole with the least effect on hepatic microsomal drug-metabolizing enzymes

Fluconazole

22

Causes "shake and bake" syndrome (chills and fever caused by infusion)

Amphotericin B (premedication is required)

23

DOC for Coccidioides immitis infection

Fluconazole