Bacterial Cell Wall Synthesis Inhibitors Flashcards Preview

Pharmacology > Bacterial Cell Wall Synthesis Inhibitors > Flashcards

Flashcards in Bacterial Cell Wall Synthesis Inhibitors Deck (31)
1

MOA of beta-lactam antibiotics

Binds to PBPs inhibiting transpeptidation reaction

2

Beta-lactamase inhibitors

Clavulanic acid
Sulbactam
Tazobactam

3

Renal tubular reabsorption of penicillin is inhibited by?

Probenecid

4

A very narrow spectrum beta lactam which causes interstitial nephritis

Methicillin

5

A very narrow spectrum beta lactam which causes neutropenia

Nafcillin

6

Very narrow spectrum beta lactams

Methicillin
Nafcillin
Oxacillin
Cloxacillin

7

Antimicrobial coverage of very narrow spectrum beta lactams

Staphylococcal infections; they are resistant to inactivation by beta-lactamase (penicillinase)

8

Narrow spectrum beta lactams

Penicillin G
Penicillin V

9

Antimicrobial coverage of narrow spectrum beta lactams

Streptococcal
Pneumococcal
Meningococcal
Syphilis

10

Extended spectrum beta lactams

Ampicillin
Amoxicillin

11

Antimicrobial coverage of extended spectrum beta lactams

Listeria
E. coli
Proteus
H. influenzae
Moraxella

12

Causes pseudomembranous colitis and rash

Ampicillin

13

Extended spectrum beta lactams have synergistic effect with?

Aminoglycosides

14

Antipseudomonal penicillins

Take Care of Pseudomonas
Ticarcillin
Carbenicillin
Piperacillin

15

Antimicrobial coverage of Antipseudomonal penicillins

Pseudomonas
Enterobacter
Klebsiella

16

1st generation cephalosporins

FADer, help me FAZ my PHarmacology boards
Cefadroxil
Cefazolin
Cephalotin
Cephapirin
Cephradine
Cephalexin

17

Used for surgical prophylaxis

1st gen cephalosporin

18

Increases the toxicity of aminoglycosides

Cephalosporins

19

Antimicrobial coverage of 1st gen cephalosporins

PEcKs 1st
Proteus
E. coli
Klebsiella

20

Antimicrobial coverage of 2nd gen cephalosporins

1st gen plus
Haemophilus
Enterobacter
Neisseria
Serratia

21

Causes disulfiram reaction

Cefamandole
Cefotetan
Cefoperazone

22

3rd gen cephalosporins

Cefetamet
Cefpodoxin
Cefoperazone
Cefotaxime
Cefixime
Ceftriaxone
Ceftazidime
Ceftizoxime
Ceftibuten

23

Antipseudomonal penicillins

Ceftazidime
Cefepime
Cefoperazone

24

Miscellaneous beta lactams

Imipenem-cilastatin
Ertapenem
Meropenem

25

Inhibits renal metabolism of imipenem

Cilastatin

26

MOA of vancomycin

Inhibits cell wall synthesis by binding to D-Ala-D-Ala terminus of nascent peptidoglycan

27

Indications for vancomycin

MRSA
Pseudomembranous colitis

28

Causes red man syndrome, neprotoxicity, and ototoxicity

Vancomycin

29

Antibiotics of last resort

I AM your Last Shot at Victory
Imipenem
Amikacin
Meropenem
Linezolid
Streptogramins
Vancomycin

30

Indication of cycloserine

Drug-resistant TB (2nd line drug)

31

Bactericidal antibiotics

Very Finely Proficient At Murder
Vancomycin
Fluoroquinolones
Penicillins
Aminoglycosides
Metronidazole