Corticosteroids and Antagonists Flashcards Preview

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Flashcards in Corticosteroids and Antagonists Deck (24)
1

Intermediate-acting glucocorticoids

Triamcinolone
Paramethasone
Fluprednisolone

2

Highest anti inflammatory effect

Betamethasone

3

Used for acute adrenal insufficiency, insect bites, contact dermatitis, status asthmaticus, and thyroid storm

Hydrocortisone

4

Used for autoimmune and neoplastic diseases as well as for prevention of organ transplant rejection

Prednisone

5

Hastens fetal lung maturation

Betamethasone
Dexamethasone

6

Glucocorticoid with the highest topical activity

Dexamethasone

7

Glucocorticoid with the longest duration of action

Dexamethasone (24-36hrs)

8

Highest salt-retaining property

Fludrocortisone

9

Used for chronic adrenal insufficiency (Addison's disease), CAH, and as an adrenal replacement therapy post-adrenalectomy

Fludrocortisone (mineralocorticoid)

10

Drugs which inhibit adrenal steroid synthesis

Ketoconazole
Aminoglutethimide
Metyrapone

11

Inhibits desmolase, blocking conversion of cholesterol to pregnenolone which leads to reduced synthesis of all hormonally active steroids

Aminoglutethimide
(Corticosteroid antagonist)

12

Drugs used for the treatment of Cushing's syndrome

Aminoglutethimide
Ketoconazole
Metyrapone

13

DOC for pregnant patients with Cushing's syndrome

Metyrapone

14

MOA of metyrapone

Inhibits 11B-hydroxylase, interfering with cortisol and corticosterone (aldosterone) synthesis

15

In the normal adult, in the absence of stress, how much cortisol is secreted daily?

10-20mg

16

Conditions where corticosteroid-binding globulin is increased

Pregnancy
Estrogen administration
Hyperthyroidism

17

Peak of ACTH secretion occurs when?

Early morning hours and after meals

18

Dexamethasone suppression test result:
Low ACTH
High cortisol

Cortisol-producing adrenal tumor

19

Dexamethasone suppression test result:
High ACTH
High cortisol

Ectopic ACTH-producing tumor

20

Dexamethasone suppression test result:
Low ACTH
Low cortisol

Normal

21

Dexamethasone suppression test result:
Morning cortisol concentration: >5mcg/dL

Cushing's syndrome

22

Used for the treatment of primary aldosteronism

Spironolactone

23

Used in the treatment of hirsutism in women

Spironolactone

24

Long-acting glucocorticoids

Betamethasone
Dexamethasone