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Principles of disease (Ross Lilley) > Antifungals > Flashcards

Flashcards in Antifungals Deck (20):
1

which drugs bind to ergosterol, increasing membrane permeability?

Polyenes

2

what are some examples of polyenes?

amphotericin B
nystatin

3

what is amphotericin B used to treat?

serious yeast and filamentous fungal infections IV

4

what is nystatin used to treat?

yeast and filamentous fungal infections topical use only

5

toxixcity of amphotericin B

it has extreme hepatic, renal, cardiac toxicity

6

drugs that inhibit ergosterol synthesis

azoles
allyamines

7

subclasses of azoles

limidazoles
triazoles

8

examples of limidazoles

Miconazoles
ketoconazoles

9

what does the limidazole miconazole treat and how is it administered?

internal and external infections including yeats and dermatophytes.
topically and orally

10

what does the limidazole ketoconazole treat and how is it administered?

topical infections
topically and orally

11

give examples if triazoles

fluconazole
itraconazole
voriconazole

12

what does the triazole fluconazole treat and how is it administered?

yeast infections (no activity against filamentous fungi)
some resistance by candida albicans.
orally and parenterally

13

what does the triazole itraconazole treat and how is it administered?

yeasts and filamentous fungi
given orally and IV

14

what does the triazole voriconazole treat and how is it administered?

aspergillus and is administered orally and IV

15

give and example of an allyamine

terbinafine

16

what is the action of terbinafine and how is it administered?

dermatophytes given orally for serious infection, given topically for mild

17

what is the action of the echinocandins?

inhibit glucanpolysaccharide synthesis

18

what are the three echinocandins

caspofungin
mycafungin
anidulafungin

19

what do the echinocandins act against?

fungicidal against candida species, serious infections
inhibit growth of some aspergillus spp. , serious infections

20

how are echinocandins administered?

IV