Tumour pathology important genes etc. Flashcards Preview

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Flashcards in Tumour pathology important genes etc. Deck (47)
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1

what does the proto-oncogene sis code for?

the growth factor PDGF

2

how does the proto-oncogene sis become an oncogene?

overexpression

3

which cancers does the over expression of sis cause?

astrocytoma, osteosarcomma

4

what does the proto-oncogene erb-B2 code for?

Growth factor receptor: EGF-receptor family

5

how does the proto-oncogene erb-B2 become an oncogene?

amplification

6

which cancers are caused by the amplification of erb-B2 cause?

breast, ovarian, lung, stomach

7

what does the proto-oncogene ras code for?

signal transducers: GTP-binding

8

how does the proto-oncogene ras become an oncogene?

point mutation

9

which cancers are caused by a point mutation of the proto-oncogene ras?

lung, colon, pancreas, leukaemia

10

what does the proto-oncogene myc code for?

nuclear regulatory protein: transcriptional activators

11

what turns the proto-oncogene myc into an oncogene?

translocation

12

which cancers is caused by the translocation in the myc gene?

Burkitt lymphoma

13

what does the proto-oncogene cyclin D code for?

the cell cycle regulator cyclin

14

which cancers is caused by translocation of the proto-oncogene cyclin D?

mantle cell lymphoma

15

which cancers are caused by the amplification of the proto-oncogene cyclin-D?

breast, liver, oesophageal

16

what does the proto-oncogene CDK4 code for?

cell cycle regulators: cyclin dependent kinases

17

which cancers are causes by the amplification if the proto-oncogene CDK4 turning it into an oncogene?

melanoma, sarcoma

18

what is the function of the tumour suppressor gene APC?

signal transduction

19

which cancers are caused by a somatic mutation in the APC tumour suppressor gene?

gastric, colon, pancreas, melanoma

20

which cancers are caused by an inherited mutation in the APC tumour suppressor gene?

FAP colon cancer

21

what is the function of the tumour suppressor gene p53?

cell cycle/ apoptosis after DNA damage

22

which cancers are caused by a somatic mutation in the p53 gene?

most cancers

23

which cancers are caused by an inherited mutation in the p53 gene?

Li-Fraumeni syndrome: causes multiple carcinomas and sarcomas

24

what is the function of the tumour suppressor gene Rb?

cell cycle regulation

25

which cancers are caused by a somatic mutation in the Rb gene?

retinoblastoma, colon, lung, breast carcinomas

26

which cancers are caused by an inherited mutation in the Rb gene?

retinoblastoma and osteosarcoma

27

what is the function of the tumour suppressor gene P16 (INK4a)?

inhibits CDK's

28

which cancers are caused by a somatic mutation in the P16 (INK4a) gene?

pancreatic, oesophageal carcinomas

29

which cancers are caused by a inherited mutation in the P16 (INK4a) gene?

malignant melanoma

30

what is the purpose of the tumour suppressor genes BRCA-1 and BRCA-2?

DNA repair