antiviral drugs Flashcards Preview

Principles of disease (Ross Lilley) > antiviral drugs > Flashcards

Flashcards in antiviral drugs Deck (24):
1

what are the anti herpes drugs ?

aciclovir
famciclovir
foscarnet
valaciclovir
valganiclovir
ganiclovir
cidofovir

2

which of the anti herpes drugs are nucleoside analogues that interfere with nucleic acid synthesis?

aciclovir
famciclovir
valaciclovir
ganiclovir
valganiclovir

3

what are the anti-HIV drugs?

3 used together:
zidovudine
nevirapine
saquinavir

and also:
lamivudine

4

which drugs are used against chronic Hepatitis B and C infections?

Interferon-α
ribavavin
lamivudine
adefovir
dipivoxil

5

which drugs are used against viral respiratory infections?

zanamavir
oseltamivir
ribavarin

6

what does aciclovir treat and how is it administered?

HSV and VZV (varicella zoster virus)
it is given IV for severe infections eg. VZV pneumonitis and hereps encephalitis
orally and topically for HSV

7

what are famiclovir and valaciclovir used to treat and how are they administered?

HSV and Shingles
orally

8

what is ganciclovir used to treat?

CMV- life and sight threatening infections

9

what is valganciclovir used to treat?

prodrug if ganciclovir so can be given orally to treat CMV

10

what is the toxicity of ganciclovir and valganciclovir?

toxic to bone marrow

11

what is foscarnet used to treat?

HSV, VZV and CMV resistant to nucleoside analogues

12

how is foscarnet administered?

IV

13

what is the toxicity of foscarnet?

highly nephrotoxic

14

what is cidofovir used to treat?

CMV retinitis

15

how does zidovudine affect the HIV virus?

it is a nucleoside analogue so interferes with nucleic acid synthesis

16

how does nevirapine affect the HIV virus?

non-nucleoside reverse transcriptase inhibitor

17

how does saquinavir affect the HIV virus?

protease inhibitor

18

what is Interferon-α used to treat and how is it administered?

selected chronic hep. B and C infections, administered subcutaneously

19

what are side affects of Interferon-α?

serious

20

what is rabavavin used to treat?

chronic hep. C occasionally for severe respiratory syncytial virus (RSV)

21

how is ribabvavin administered?

orally

22

what is lamivudine used to treat and how is it administered?

mainly HIV but also Hep. B
given orally

23

what is adefovir used to treat and how is it administered?

Hep. B
given orally

24

what do zanamavir and oseltamivir treat?

influenza A and B