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Flashcards in mediators of inflammation Deck (15)
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1

what are the cell surface mediators of acute inflammation?

ICAM-1 and P selectin

2

what is the function of cell surface mediators?

allows neutrophils to adhere to endothelial cells in blood vessels

3

what is the function of histamine in acute inflammation and where is it releases from?

it is released from mast cells and is IgE mediated. It causes vasodilation and increaesed permeability of the blood vessels

4

what is the function of seratonin in acute inflammation and where is it released from?

released from platelets when they degranulate. It causes vasoconstriction

5

what is the function of prostaglandins in acute inflammation?

promote the effects of histamine

6

what is the function of the prostaglandin thromboxane in acute inflammation?

promotes platelet aggregation and vasoconstriction

7

what is the function of leukotrienes in acute inflammation and where is it released from?

they are secreted by neutrophils and they are vasoactive, constricting smooth muscle and increasing vessel permeability

8

what is the function of the inflammatory mediators omega-3 polyunsaturated fatty acids?

decreases the release of leukotrienes and other arachadonic acid metabolites

9

what is the function of the inflammatory mediator platelet activating factor?

reduces vessel permeability by enhancing platelet degranulation at the site of the injury

10

what is the function of cytokines and chemokines in inflammation?

small molecules produced by macrophages, lymphocytes and endothelium in response to inflammatory stimuli. These attract more inflammatory factors by chemotaxis. examples incude TNF-α and interleukin 1

11

what is the function of nitric oxide in inflammation?

produced by various cells on demand, it causes smooth muscle to relax, is an anti-platelet and also regulates the recruitment of leukocytes

12

what is the function of oxygen free radicals in an inflammatory response?

released by neutrphils on phagocytosis and amplify other mediator effects

13

what is the role of blood coagulation pathways in inflammation

clots fibrinigen in the exudate and acts to localise inflammatory effects and also causes vasoconstriction

14

what is the role of the kinin system in inflammation?

bradykinin causes pain, this is a protective function to limit exposure

15

what is the function of the complement cascade in inflammation?

ties inflammation with the immune system. The active components stimulate increased permeability, chemotaxis, phagocytosis and cell breakdown