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Flashcards in acute inflammation 2 Deck (23)
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1

peritonitis

inflammation of the peritoneal cavity

2

meningitis

inflammation of the meninges

3

appendicitis

inflammation of the appendix

4

pneumonia

inflammation of the cavities in the lungs

5

pneumonitis

inflammation of the lung tissue

6

action of neutrophils

-mobile phagocytes
-possess oxidants and enzymes which it releases.

7

chemotaxis

movement of a cell along a concentration gradient of a chemical.

8

what happens to neutrophils when the release granules

they die

9

pus

mixture of fluid, bits of cell, organisms and endogenous proteins

10

fibrinogen

coagulation factor - forms fibrin and clots exudate

11

where mediators of acute inflammation are found

-on endothelial cell surface membrane
-released form cells
-in plasma

12

collective effects of mediators

-vasodilatation
-increased permeability
-neutrophil adhesion
-chemotaxis
-itch and pain

13

cell surface mediators, function and examples

-help neutrophils stick to endothelial cells. eg. P-selectin and ICAM-1

14

mediators released from cells

-histamine
-serotonin
-prostaglandins
-leukotrienes
-omega-3polyunsaturated fatty acids
-platelet activated factor
-cytokine and chemokines
-NO
-oxygen free radicals

15

enzyme cascades in plasma,

-blood coagulation pathways (clots fibrinogen)
-fibrinolysis (breaking down of fibrin)
-kinin system (hormonal system involved with coagulation, inflammation, pain and blood pressure)
-complement cascade (ties inflammation with immune system)

16

immediate effects of acute inflammation

pyrexia- raised temp.
feel unwell-malaise, anorexia, nausea
neutrophilia- raised WBC count

17

longer term effects of acute inflammation

-lymphadenopathy-regional lymph node enlaegement
-weight loss
-anaemia

18

abscess

collection of pus under pressure

19

organisation after acute inflammation

-granulation tissue forms
-healing and repair
-leads to fibrosis and formation of a scar

20

septicaemia

growth of bacteria in blood

21

bacteraemia

bacteria in blood

22

toxaemia

toxic products in blood

23

shock

an inability to perfuse (supply with a fluid, circulation) tissues