Flashcards in therapeutic options: cancer Deck (21)
preventative measures for cancer
treatments of cancer
what type of food stuff probably causes CRC?
what type of food stuff probably causes breast cancer?
general advise for reducing cancer risk (diet and lifestyle)
-eat your 5 a day
-exercise 30 mins a day
cancers screened for
cervical cancer-smeer test
breast cancer- mammography
CRC- faecal occult blood test
inherited cancers that families are genetically screened for
familial adenomatous polyposis (causing CRC)
breast cancer caused by BRCA1 and BRCA2
local treatments of cancers
- ablation (freezing, radio-frequency, etc - isolated limb perfusion
- hormonal therapy
- whole body irradiation (for bone marrow transplants)
what is a requirement of surgery in order for it to be successful?
when is radiotherapy used?
-to shrink a tumour so it becomes operable
-to treat inoberable lesions
what does radiotherapy require in order to be successful?
5 R's of radiobiology
repair (5 R's)
radiation must be given in the correct doses to cause cancer cell damage but limit natural cell death
re-assortment (5 R's)
cancer cells must be targeted in the phase of the cell cycle at which they are most susceptible to radiation damage.
re-oxygenation (5 R's)
cancer cells must be oxygenated so they move through the cell cycle to a stage that will allow them to be killed, if they are stuck in G1 treatment will have no effect
re-population (5 R's)
normal cells need to repopulate areas of dead cancer cells. and these areas can't be repopulated by more cancer cells.
radiosensitivity (5 R's)
different cells have different responses to radiation
when are cytotoxic drugs used?
- for curative treatment
- adjuvant treatment (risk of cancer returning)
-neoadjuvant (treatment given to shrink tumour before therapy
-innate immune system
-programmed cell death pathway
-CAR T-cell therapy