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Flashcards in chronic inflammation 2 Deck (16)
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1

what characterises granulomatous inflammation

the presence of granulomas

2

idiopathic disease

disease with no known cause

3

what stimulates granulomatous inflammation?

an indigestible antigen

4

what are granulomas ?

an aggregate of epithelioid macrophages also contain neutrophils and eosinophils.

5

giant cells

a fusion of macrophages to form larger cells, so they have a large cytoplasm and many nuclei.

6

what disease are langhans cells associated with

TB

7

Langhans cell characteristics

peripheral rim of nuclei, large eosinophilic cytopasm

8

infectious granulomatous diseases

tuberculosis
leprosy
syphilis

9

non-infectious granulomatous diseaese

rheumatoid arthritis
Crohn's disease
sarcoidosis- granulomas form in lungs

10

sequence of events in wound healing

1. injury
2. blood clot
3. acute inflammation
4. fibrin
5. many growth factors and cytokines become involved
6. granulation tissue growth and angiogenesis
7. phagocytosis of fibrin
8. myofibroblasts move in and lay down collagen
9. scar contracts
10. re-epithelialisation

11

healing by primary intention characteristics

minimal gap and small blood clot.
small amount of granulation tissue
small linear scar

12

healing by secondary intention

lots of granulation tissue ingrowth. contraction of skin around wound and large amount of scarring.

13

factors favouring wound healing and repair

-cleanliness
-apposition of edges (no haematoma)
-sound nutrition
-metabolic stability and normality
-normal inflammatory and coagulation mechanisms

14

factors impairing wound healing

-dirty, gaping wound, large haematoma
-poorly nourished, lack of vitamins C, A
-abnormal carbohydrate metabolism, diabetes, corticosteroid therapy
-inhibition of angiogenesis

15

angiogenesis function in healing

it enables blood supply to enter damaged tissue, bringing with it the essential cells, proteins and other components essential for healing.

16

process of fracture healing

1. acute inflammation
2. organisation
3. granulation tissue formation containing osteoblasts
4. macrophages remove debris
5. osteoblasts lay down woven bone
6. the bone then undergoes remodelling- osteoclasts remove dead and woven bone and replace it with lamellar (sheet) bone forming cortical and trabecular bone in the right places.