Flashcards in chronic inflammation 2 Deck (16)
what characterises granulomatous inflammation
the presence of granulomas
disease with no known cause
what stimulates granulomatous inflammation?
an indigestible antigen
what are granulomas ?
an aggregate of epithelioid macrophages also contain neutrophils and eosinophils.
a fusion of macrophages to form larger cells, so they have a large cytoplasm and many nuclei.
what disease are langhans cells associated with
Langhans cell characteristics
peripheral rim of nuclei, large eosinophilic cytopasm
infectious granulomatous diseases
non-infectious granulomatous diseaese
sarcoidosis- granulomas form in lungs
sequence of events in wound healing
2. blood clot
3. acute inflammation
5. many growth factors and cytokines become involved
6. granulation tissue growth and angiogenesis
7. phagocytosis of fibrin
8. myofibroblasts move in and lay down collagen
9. scar contracts
healing by primary intention characteristics
minimal gap and small blood clot.
small amount of granulation tissue
small linear scar
healing by secondary intention
lots of granulation tissue ingrowth. contraction of skin around wound and large amount of scarring.
factors favouring wound healing and repair
-apposition of edges (no haematoma)
-metabolic stability and normality
-normal inflammatory and coagulation mechanisms
factors impairing wound healing
-dirty, gaping wound, large haematoma
-poorly nourished, lack of vitamins C, A
-abnormal carbohydrate metabolism, diabetes, corticosteroid therapy
-inhibition of angiogenesis
angiogenesis function in healing
it enables blood supply to enter damaged tissue, bringing with it the essential cells, proteins and other components essential for healing.